Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness

British Journal of Cancer
D N AryeeH Kovar

Abstract

The nm23-H1 gene is a putative metastasis-suppressor gene encoding a 17 kDa protein with nucleoside diphosphate kinase activity. Expression of nm23-H1/NDPK-A correlates inversely with the metastasising potential of some human tumours and experimental animal cells. No nm23 expression studies exist for human malignant lymphomas so far. In this study, we examined nm23-H1 expression by Northern and immunohistochemical analysis in 106 primary lymphoma samples from patients with Hodgkin's disease (HD) (n = 15), high-grade non-Hodgkin's lymphoma (NHL) from different lineages (n = 71) and low-grade NHL (n = 20). Both inter- and intra-subtype variations in nm23-H1/NDPK-A expression levels were demonstrated by all disease subtypes. Besides this heterogeneity, a general trend towards highly malignant samples expressing higher nm23-H1/NDPK-A, levels than the low-grade lymphomas was observed. Both adult and childhood HD and high-grade NHL samples exhibited significantly higher NDPK-A expression than the low-grade NHL found only in adults. High nm23-H1/NDPK-A levels in lymphoma samples did not always reflect proliferative activity of tumour cells as monitored by Ki-67 antigen staining. Fifty samples were further investigated for possible mut...Continue Reading

Citations

Aug 8, 2006·Journal of Korean Medical Science·Ju-Han LeeInsun Kim
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sema BircanL J Medeiros
Jun 5, 1998·The Journal of Biological Chemistry·R WillemsH Slegers
Jul 11, 2006·International Journal of Cancer. Journal International Du Cancer·Véronique OuelletAnne-Marie Mes-Masson
Nov 18, 2003·British Journal of Haematology·Nozomi NiitsuUNKNOWN Adult Lymphoma Treatment Study Group, ALTSG
Sep 24, 2011·Advances in Hematology·Junko Okabe-KadoYasuhiko Kaneko
Oct 11, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Choon-Yee Tan, Christina L Chang
Aug 3, 2002·Leukemia & Lymphoma·Junko Okabe-Kado
Jan 7, 2000·Journal of Cellular Physiology·D LombardiM G Paggi
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nozomi NiitsuMasami Hirano
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Markus RoesslerMichael Tacke
Jul 6, 2000·Archives of Medical Research·D Utrera-BarillasL Benítez-Bribiesca
Nov 7, 2000·Cancer Genetics and Cytogenetics·G CipolliniM A Caligo
Jul 24, 2002·Experimental Hematology·Roel WillemsDirk R Van Bockstaele
Feb 4, 2009·Journal of Proteome Research·Hye-Jung KimCheolju Lee
Dec 31, 2003·Gene·Max M van Noesel, Rogier Versteeg

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.