PMID: 6171859Apr 1, 1981Paper

Variability of plasma proteins according to molecular size. Long-term and short-term intra-individual variation

Scandinavian Journal of Clinical and Laboratory Investigation
P Hyltoft PetersenK Thygesen

Abstract

The intra-individual variations in serum concentrations of alpha 1-antitrypsin, albumin and alpha 2-macroglobulin were determined using high precision analytical methods. The long-term (3 months) variations were 8.2% for alpha 1-antitrypsin and 2.9% for alpha 2-macroglobulin in five males and five females. The coefficients of variation for albumin were 1.5 and 3.4% for males and females, respectively. In males the long-term variations of albumin and alpha 2-macroglobulin were highly correlated. The short-term (2 days) intra-individual variations in six males were 2.5, 3.8 and 3.4% for alpha 1-antitrypsin, albumin and alpha 2-macroglobulin respectively (coefficients of variation). A diurnal variation was found for albumin with maximal concentrations at 18.00 hours. At 6.00 and 10.00 hours the fractional concentrations of alpha 1-antitrypsin and albumin were lower than for alpha 2-macroglobulin. The variations of the three proteins were positively correlated.

References

Mar 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·E Panek, J Steinmetz
Oct 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·H NielsenV Binder
Mar 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·E M VeysJ van der Jeught
Jan 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·P H Petersen, T Dreyer
Jan 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·P Hyltoft PetersenN Tryding

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Citations

May 19, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Natàlia Iglesias CanadellPer E Jørgensen
Jan 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·S Antonsen
Jan 8, 2013·Biomedit︠s︡inskai︠a︡ khimii︠a︡·N A PakharukovaI M Larina
Apr 1, 1990·Journal of Endocrinological Investigation·L KayserJ E Hansen
Oct 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·A M GerdesV Bonnevie-Nielsen

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