PMID: 108715Mar 14, 1979

Variability of prolactin response to intravenous and intramuscular haloperidol in normal adult men

Psychopharmacology
R T Rubin, S E Hays

Abstract

Serum prolactin (PRL) concentrations were monitored in seven normal adult men for 1 h before and 7 h after i.v. and i.m. injection of 0.25 mg and 0.50 mg haloperidol. The magnitude of the PRL response was dose-related but quite variable across subjects. The patterns of PRL secretion over the 7 h post-injection period also varied greatly among the subjects. Differences in serum heloperidol concentrations accounted for 88% of the variability in the magnitude of the PRL response to the 0.5 mg IM haloperidol dose, but only accounted for 60% of the PRL variability following the 0.5 mg IV dose. The pattern of haloperidol disappearance from serum was similar across the seven subjects and thus unrelated to the variable patterns of PRL response.

References

Oct 1, 1977·Biochemical Pharmacology·P Seeman
Jan 1, 1978·Archives of General Psychiatry·P H GruenF S Halpern
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R T RubinW D Odell
Oct 1, 1976·Acta Psychiatrica Scandinavica·F BrambillaF Riggi
Jan 15, 1977·Life Sciences·B R ClarkR T Rubin
Feb 21, 1977·European Journal of Pharmacology·H Y MeltzerS M Paul
Apr 1, 1977·Clinical Pharmacology and Therapeutics·G NikitopoulouM Lader
Nov 1, 1977·The Journal of Clinical Endocrinology and Metabolism·G LangerM Solomon
Sep 2, 1976·The New England Journal of Medicine·David J Greenblatt, J Koch-Weser
Mar 1, 1976·Archives of General Psychiatry·H Y Meltzer, V S Fang
May 28, 1976·Psychopharmacologia·R T RubinB B Tower
Jan 1, 1974·Psychopharmacologia·J A ClemensB D Sawyer
Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·G L NoelA G Frantz
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·Y N SinhaW P VanderLaan

Citations

Jan 1, 1991·Journal of Neural Transmission. General Section·M MarkianosE Bistolaki
Apr 1, 1983·Psychiatry Research·M R Cohen
Jan 1, 1984·Psychiatry Research·G K RavichandranR C Smith
Jan 1, 1981·Psychoneuroendocrinology·S E Hays, R T Rubin
Jan 1, 1984·Psychoneuroendocrinology·M SteinerR T Rubin
Jan 1, 1984·Psychoneuroendocrinology·V J MenonD R London
Jan 1, 1988·Psychoneuroendocrinology·G M AsnisU Halbreich
Mar 1, 1991·Baillière's Clinical Endocrinology and Metabolism·S Checkley
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·J G ModellJ Y Lee
Oct 1, 1990·Acta Psychiatrica Scandinavica·J KulkarniD L Copolov
May 1, 1997·Journal of Cognitive Neuroscience·M Luciana, P F Collins
Jun 1, 1980·The Australian and New Zealand Journal of Psychiatry·G F Johnson, G E Hunt
Sep 3, 2004·Journal of Clinical Pharmacology·Anne T HarveySheldon H Preskorn
May 1, 1984·British Journal of Obstetrics and Gynaecology·M SteinerR T Rubin
Nov 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·T KolakowskaM Gelder

Related Concepts

Haldol
Intramuscular Injection
Intravenous Injections
Prolactin

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