Variability of response to methadone: genome-wide DNA methylation analysis in two independent cohorts

Epigenomics
Cynthia Marie-ClaireFlorence Vorspan

Abstract

Methadone maintenance treatment is characterized by large interindividual dose variability. The aim of this study was to evaluate whether DNA methylations are associated with daily dose of methadone. Subjects stabilized at high (n = 12) or low (n = 12) methadone doses were selected from two independent cohorts (French and Swiss). DNA methylation patterns were analyzed using HumanMethylation450 BeadChips. In total, 584 differentially methylated sites were identified in the French cohort corresponding to 352 genes. Of these, 26 were replicated in the Swiss cohort. The methylation status of 13 genes varied similarly in both cohorts and calcium signaling pathway was significantly enriched. Our results indicate that differentially methylated sites are associated with methadone daily dose and give insights into the molecular pathways underlying this interindividual dose variability.

References

Jan 1, 1994·The International Journal of the Addictions·E T Moolchan, J A Hoffman
Mar 23, 1999·JAMA : the Journal of the American Medical Association·E C StrainM L Stitzer
Aug 27, 1999·The Journal of Nervous and Mental Disease·V L KingA F Mirsky
Feb 14, 2002·Drug and Alcohol Dependence·Magí FarréJordi Camí
Dec 13, 2005·Clinical Pharmacology and Therapeutics·Séverine CrettolChin B Eap
Apr 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Daniel T BarrattAndrew A Somogyi
Dec 21, 2006·Clinical Pharmacology and Therapeutics·Séverine CrettolChin B Eap
Dec 21, 2006·Clinical Pharmacology and Therapeutics·Janet K CollerAndrew A Somogyi
May 16, 2007·Journal of Clinical Psychopharmacology·Claude UehlingerChin B Eap
Aug 2, 2007·Therapeutic Drug Monitoring·Nadia Fucci, Nadia De Giovanni
Jan 15, 2008·Addiction·Amy GibsonSusannah O'Brien
Feb 8, 2008·BMC Bioinformatics·Mark J DunningMatthew E Ritchie
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dirk MoserJobst Meyer
Jul 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A NielsenMary Jeanne Kreek
Aug 9, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Séverine CrettolChin B Eap
Nov 20, 2008·JAMA : the Journal of the American Medical Association·Herbert D Kleber
Dec 23, 2008·Drug and Alcohol Dependence·David H EpsteinKenzie L Preston
Nov 6, 2009·The International Journal of Neuropsychopharmacology·Nicolas TournierXavier Declèves
Nov 17, 2009·Neurochemistry International·Tipa ToskulkaoPiyarat Govitrapong
Feb 16, 2010·Journal of Addictive Diseases·Ayman FareedKaren Drexler
Apr 22, 2010·Journal of Addictive Diseases·Mary Jeanne KreekBrenda Ray
Jun 2, 2010·The Pharmacogenomics Journal·B OnedaC B Eap
Oct 20, 2010·The International Journal on Drug Policy·Adam R WinstockToby Lea
Jun 23, 2011·Journal of Clinical Psychopharmacology·Sheng-Chang WangYu-Li Liu
May 9, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Einat PelesMiriam Adelson
Jul 4, 2012·The American Journal of Drug and Alcohol Abuse·Louise MullenIde Delargy
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Daniel T BarrattAndrew A Somogyi
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Divya MehtaElisabeth B Binder
May 2, 2013·BMC Genomics·Ruth PidsleyLeonard C Schalkwyk
Dec 3, 2013·Journal of Psychiatric Research·Nina H van MilHenning Tiemeier

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Citations

Nov 8, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Timothy M BarrowLiqiong Guo
Aug 26, 2017·Pharmacogenomics·Cynthia Marie-ClaireFlorence Vorspan
Mar 16, 2019·Scientific Reports·Janitza L Montalvo-OrtizJoel Gelernter
Mar 26, 2019·British Journal of Clinical Pharmacology·Caroline Victorri-VigneauMarie Grall-Bronnec
Jun 5, 2020·Clinical Epigenetics·Jose Vladimir Sandoval-SierraKhyobeni Mozhui
Jan 9, 2021·Drug Development Research·Florence VorspanVanessa Bloch
Mar 3, 2021·Drug and Alcohol Dependence·Philip J FredaHenry R Kranzler

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Methods Mentioned

BETA
blood collection
methylation profiling
genotyping
pharmacotherapy

Clinical Trials Mentioned

NCT00894452

Software Mentioned

mixtools
Gene Set Analysis Toolkit
Illumina
R stats package )
wateRmelon
R stats package
WebGestalt
R

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