Variability of Symmetric Dimethylarginine in Apparently Healthy Dogs

Journal of Veterinary Internal Medicine
M A KopkeA Gal

Abstract

Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population-based reference intervals. To determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD ) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs. Twenty apparently healthy adult dogs owned by clients or staff at a veterinary teaching hospital. Prospective, observational study. Blood was collected from each dog on 9 occasions, and SDMA and sCr were measured in duplicate using commercially available assays. SDMA and sCr had intermediate and low IOI values of 0.87 and 0.28, respectively. The CD of SDMA and sCr, was 1.34 µg/dL and 0.89 µmol/L, respectively. The sample numbers required for estimation of an individual's HSP (with 90 and 95% CI) for SDMA and sCr were 8 and 45, and 2 and 12 sequential measurements, respectively. Based on our findings, in comparison to sCr, SDMA is better suited for use wit...Continue Reading

References

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Citations

Jun 5, 2020·Veterinary Sciences·Eleonora GoriVeronica Marchetti
Oct 3, 2018·Toxicologic Pathology·Mary B Nabity
Dec 1, 2018·Journal of Veterinary Internal Medicine·Matthew A KopkeArnon Gal
Jul 28, 2020·Veterinary Clinical Pathology·Jennifer M PrietoMark E Peterson
Nov 13, 2020·The Journal of Veterinary Medical Science·Yuichi MiyagawaNaoyuki Takemura
Nov 14, 2020·The Journal of Small Animal Practice·H J SargentR E Jepson
Jul 9, 2021·Journal of Animal Physiology and Animal Nutrition·Veronika HajekPetra Kölle
Jun 11, 2021·Equine Veterinary Journal·Hsiao-Chien LoHeidrun Gehlen
Sep 8, 2021·Environmental Science and Pollution Research International·Youssef M Y ElgazzarMahmoud A Y Helal

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Methods Mentioned

BETA
blood collection
ELISA

Software Mentioned

lmerTest
lme4

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