PMID: 15338804Sep 2, 2004Paper

Variability of symptoms in mild persistent asthma: baseline data from the MIAMI study

Respiratory Medicine
Robert S ZeigerMIAMI Study Research Group

Abstract

To describe the variability of the asthma phenotype in patients with mild persistent asthma enrolled in the Mild Asthma Montelukast versus Inhaled Corticosteroid (MIAMI) study. The variability of asthma rescue-free days, asthma symptoms, albuterol use, medical resource use, and exercise Limitations among patients with documented mild persistent asthma was compared between the month before study enrollment and the last 2 weeks of the run-in period. Patients eligible for randomization (n = 400), aged 15-85 years, exhibited symptoms (mean +/- SD) 3.6 +/- 1.3 days/week, beta-agonist use 3.5 +/- 1.3 days/week, and normal FEV1 (94.0 +/- 9.9% predicted) during the last 2 weeks of the run-in period. In the year before enrollment, medical intervention for asthma flares was common: 38.5% made office visits, 15.8% had oral corticosteroids, and 8.3% required emergency room or hospitalized care. In the month before enrollment, 11.8% experienced daily symptoms, and 28.3% had limitations of normal activity. Patients with daily symptoms in the month before study enrollment, compared with those having less-than-daily symptoms, experienced fewer rescue-free days (P = 0.024) and had more days per week with symptoms (P = 0.008) and requiring albut...Continue Reading

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Citations

Mar 14, 2007·The Journal of Allergy and Clinical Immunology·Cynthia RandUNKNOWN MIAMI Study Research Group
Sep 3, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Philippe BareilleAlison C Donald
Jul 23, 2016·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Samir GuptaLouis-Philippe Boulet
Dec 4, 2015·Breathe·Clementine BostantzoglouMina Gaga
May 18, 2012·The Cochrane Database of Systematic Reviews·Bhupendrasinh F Chauhan, Francine M Ducharme

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