Variability of the 13C-acetate breath test for gastric emptying of liquids in healthy children

Journal of Pediatric Gastroenterology and Nutrition
B HauserY Vandenplas

Abstract

Scintigraphy is considered as the "gold standard" for measuring gastric emptying (GE). The C-acetate breath test (C-ABT) offers an attractive alternative to measure GE of liquids as it is nonradioactive. The aim of this study was to assess the variability of the C-ABT for GE of liquids in healthy children using nondispersive infrared spectrometry (NDIRS). The C-ABT was repeated at least 2 times in 21 healthy children (6 girls and 15 boys), aged between 6.2 and 16.4 years, 2 to 7 days apart. After an overnight fast, a standardized milk drink, labeled with 50 or 100 mg C-acetate according to weight, was administered. Breath samples were taken before feeding, at 5-minute intervals for the first 40 minutes and at 10-minute intervals for the following 140 minutes after feeding. Breath samples were analyzed using NDIRS, and C recovery was used to calculate values for gastric half-emptying time (t1/2), time of peak C exhalation, or gastric lag phase (tlag) and gastric emptying coefficient (GEC). Intraindividual variabilities of the parameters t1/2, tlag, and GEC were expressed as coefficient of intrasubject variation (CV). The median CV of t1/2 was 8.3% (CV range, 1.6%-16.2%; t1/2 interindividual range, 65-112 minutes; and t1/2 intrai...Continue Reading

Associated Clinical Trials

References

Mar 1, 1991·Medicine and Science in Sports and Exercise·J B Mitchell, K W Voss
Dec 1, 1988·Digestive Diseases and Sciences·J G MooreN Alazraki
Sep 1, 1987·Gastroenterology·R H GooN P Alazraki
Aug 1, 1986·Digestive Diseases and Sciences·C M BrophyA T Taylor
Jun 1, 1984·Digestive Diseases and Sciences·J G MooreN Alazraki
Apr 1, 1983·Digestive Diseases and Sciences·J G MooreF L Datz
Apr 1, 1982·Seminars in Nuclear Medicine·L S MalmudE Rock
Oct 1, 1995·Digestive Diseases and Sciences·L P DuanB Lembcke
Jul 1, 1994·Digestive Diseases and Sciences·K Hoshika
Aug 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·G Veereman-WautersE Eggermont
Mar 27, 1998·Nuclear Medicine Communications·M F KongI A Macdonald
Jul 10, 1999·Journal of Pediatric Gastroenterology and Nutrition·C BarnettR Butler
Jul 10, 1999·Journal of Pediatric Gastroenterology and Nutrition·M Van Den DriesscheG Veereman-Wauters
Apr 30, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B BradenP Ahrens
Jul 29, 2005·Journal of Gastroenterology and Hepatology·Krzysztof JonderkoBarbara Błońska-Fajfrowska

❮ Previous
Next ❯

Citations

Aug 22, 2009·Pediatric Surgery International·Hisayoshi KawaharaMasahiro Fukuzawa
Oct 24, 2006·International Journal of Clinical Oncology·Hitoshi Katai
Oct 1, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Katy M HornerNeil A King
Jul 29, 2017·Journal of Neurogastroenterology and Motility·Shinji IshiiMinoru Yagi
Dec 6, 2008·The American Journal of Clinical Nutrition·Hiroaki ZaiMasatomo Mori
Jan 24, 2007·Physiological Measurement·J M de la Roca-ChiapasM Sosa
Sep 1, 2007·Journal of Breath Research·Anil S Modak
Jun 6, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Željko BajzerGianrico Farrugia
Aug 25, 2015·Journal of Pediatric Gastroenterology and Nutrition·Bruno HauserYvan Vandenplas
Sep 19, 2018·Journal of Paediatrics and Child Health·Jody A PorterAndrew S Day
May 18, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jutta KellerBruno Hauser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.