Variability of the 13C-octanoic acid breath test for gastric emptying of solids in healthy children

Alimentary Pharmacology & Therapeutics
B HauserY Vandenplas

Abstract

To assess the intra-individual variability of the 13C-octanoic acid breath test using non-dispersive infrared spectrometry for gastric emptying of solids in healthy children. A 13C-octanoic acid breath test was performed at least two times in 19 healthy children (age 12.4 +/- 2.7 years) 2-7 days apart to measure gastric emptying of solids. Breath samples were taken before eating a 13C-octanoic acid-labelled pancake and at 15-min intervals for the following 240 min. Breath samples were analysed using non-dispersive infrared spectrometry; 13C-recovery was used to calculate values for gastric half-emptying time (t(1/2)), gastric lag phase (t(lag)) and gastric emptying coefficient. Intra-individual variability of the parameters t(1/2), t(lag) and gastric emptying coefficient were expressed as coefficient of intrasubject variation. The mean coefficient of intrasubject variation of t(1/2) was 13.3 +/- 7.9% (range 2.5-29.6%; interindividual range 99-204 min; intra-individual range 5-84 min for t(1/2)). The mean coefficient of intrasubject variation of t(lag) was 13.6 +/- 7.5% (range 0.8-27.8%) (interindividual range 65-146 min; intra-individual range 1-50 min for t(lag)). The mean coefficient of intrasubject variation of gastric empty...Continue Reading

References

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Citations

Mar 29, 2001·American Journal of Preventive Medicine·Y LeeS J Yoon
Oct 13, 2011·BMC Public Health·Muhammad Umair MushtaqArif Mahmood Siddiqui
Oct 2, 2015·European Journal of Clinical Investigation·Jutta KellerPeter Layer
Aug 19, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Caterina AnaniaClaudio Chiesa
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Oct 27, 2017·Diabetes, Obesity & Metabolism·Myfanwy C GeyerJennifer J Couper
Mar 28, 2008·Journal of Pediatric Gastroenterology and Nutrition·Rodrigo Strehl MachadoElisabete Kawakami
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Apr 15, 2015·The Journal of Clinical Endocrinology and Metabolism·Shiree J PeranoJenny J Couper
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May 7, 2010·Scandinavian Journal of Gastroenterology·Miriam E Clegg, Amir Shafat
Apr 22, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B HauserY Vandenplas
Dec 11, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Katja KovacicManu R Sood
May 18, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jutta KellerBruno Hauser

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