Variability of the initial phase of the ventilatory response to hypoxia in sleeping infants

Pediatric Research
Heidi L RichardsonRosemary S C Horne

Abstract

Most of the available data on the hypoxic ventilatory response (HVR) in infants has been obtained in quiet sleep (QS), and only one study has made repeated tests in the same infant. We aimed to gain a more complete knowledge of the maturation and consistency of the initial phase of the HVR by performing multiple tests in both QS and active sleep (AS) over the first 6 mo of life in term infants. Fifteen healthy term infants were studied with daytime polysomnography longitudinally at 2-5 wk, 2-3 mo, and 5-6 mo after birth. Each infant received multiple hypoxic (15% O2, balance N2) challenges (three or more) in both AS and QS. In AS, infants consistently aroused to hypoxia; however, in QS, infants both aroused and failed to arouse. The initial phase of the HVR varied considerably between infants with the changes in ventilation/kg [SD of inspired minute ventilation per kilogram of body weight (V(I)/kg)] being more variable during AS than QS at all three ages and overall decreasing with postnatal age in both sleep states. The variability between replicate V(I)/kg measurements was also significantly greater in AS compared with QS at 2-5 wk postnatal age. There was no evidence of habituation to repeated hypoxic tests in either sleep s...Continue Reading

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Citations

Dec 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A DarnallBenjamin M Zemel
Mar 26, 2013·Paediatric Respiratory Reviews·Rosemary S C Horne
Mar 18, 2015·Pediatric Pulmonology·Kristie L DeHaanJoanna E MacLean
Dec 17, 2009·Biological Psychology·Jorge Gallego, Boris Matrot
Sep 14, 2015·Paediatric Respiratory Reviews·Joanna E MacLeanKaren A Waters
Oct 11, 2016·Pediatric Pulmonology·Kamal AliAnne Greenough
Dec 9, 2021·Paediatric Anaesthesia·Daniel TrachselBritta S von Ungern-Sternberg

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