Variability of vascular endothelial growth factor in normal human breast tissue in vivo during the menstrual cycle

The Journal of Clinical Endocrinology and Metabolism
Charlotta Dabrosin

Abstract

Exposure to sex steroids increases the risk of breast cancer, but the mechanisms are poorly understood. Angiogenesis is crucial in tumor development and progression. Very little is known about the regulation of angiogenesis in the normal breast. Vascular endothelial growth factor (VEGF) has a key stimulatory role in angiogenesis. Interferon-inducible protein 10 (IP-10) is a potent inhibitor of angiogenesis in vivo. These factors function in autocrine/paracrine pathways; therefore, direct measurements in the target tissue are needed. I measured VEGF and IP-10 in normal human breast tissue in situ in healthy women, using microdialysis, in the follicular and luteal phase of the menstrual cycle. In breast tissue, VEGF levels increased in the luteal phase, compared with the follicular phase (17.8 +/- 4 pg/ml to 34 +/- 9 pg/ml, P < 0.05). Plasma VEGF did not show a cyclic variation (10.6 +/- 2.8 pg/ml vs. 14.6 +/- 3.5 pg/liter, P = 0.3). IP-10 levels did not vary during the menstrual cycle either in breast tissue (65 +/- 17 pg/ml vs. 75 +/- 21 pg/ml, P = 0.6) or in plasma (64 +/- 7 pg/ml vs. 81 +/- 10 pg/ml, P = 0.06). The data suggests that, in the luteal phase, VEGF and IP-10, in the normal human breast, exhibit a proangiogenic pro...Continue Reading

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Citations

Mar 29, 2006·Cell and Tissue Research·Stina GarvinCharlotta Dabrosin
Oct 8, 2005·Angiogenesis·Charlotta Dabrosin
Oct 13, 2006·Breast Cancer Research and Treatment·Ulrika W NilssonCharlotta Dabrosin
Aug 14, 2010·Journal of Mammary Gland Biology and Neoplasia·Anne-Catherine Andres, Valentin Djonov
Apr 28, 2004·Breast Cancer Research and Treatment·Charlotta DabrosinKarin Ollinger
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