Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought

Osteoarthritis and Cartilage
A E KozijnR Stoop

Abstract

Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was established by various dietary approaches. Wild-type C57BL/6J mice and genetically modified mice (hCRP, LDLr-/-. Leiden and ApoE*3Leiden.CETP mice) based on C57BL/6J background were used to investigate the contribution of inflammation and altered lipoprotein handling on diet-induced cartilage degradation. High-caloric diets of different macronutrient composition (i.e., high-carbohydrate or high-fat) were given in regimens of varying duration to induce a metabolic phenotype with aggravated cartilage degradation relative to controls. Metabolic phenotypes were confirmed in all studies as mice developed obesity, hypercholesteremia, glucose intolerance and/or insulin resistance. Aggravated cartilage degradation was only observed in two out of the twelve experimental setups, specifically in long-term studies in male hCRP and female ApoE*3Leiden.CETP mice. C57BL/6J and LDLr-/-. Leiden mice did not develop HFD-i...Continue Reading

Citations

Dec 27, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E V ChetinaE P Sharapova
May 28, 2020·International Journal of Molecular Sciences·Deyanira ContarteseMilena Fini
Jan 17, 2021·Scientific Reports·Amber T CollinsCourtney M Karner
Jun 27, 2021·Bone·Ioanna PapathanasiouAspasia Tsezou
Jun 15, 2021·Osteoarthritis and Cartilage·R Largo, G Herrero-Beaumont

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