Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants

Current Opinion in Organ Transplantation
Raja Rajalingam

Abstract

The present review summarizes the diversity of killer cell immunoglobulin-like receptors and their complex interactions with self human leukocyte antigen class I molecules that control natural killer cell function. Further, a working model has been developed illustrating the potential impact of variable killer cell immunoglobulin-like receptor-human leukocyte antigen interactions on the outcome of solid organ transplants in view of current knowledge from basic and clinical research. In addition to restraining natural killer cell function, the interaction of inhibitory receptors with cognate human leukocyte antigen class I ligands has been recently shown to set the functional threshold for natural killer cells. Therefore, the number and type of inhibitory killer cell immunoglobulin-like receptor-human leukocyte antigen class I interactions in the recipient, as well as the type of human leukocyte antigen class I ligands expressed on the allograft, can determine the degree of natural killer cell alloreactivity and have potential impact in transplant outcome. Natural killer cells can respond to allografts. The strength of that response is likely determined by the number and type of inhibitory killer cell immunoglobulin-like recepto...Continue Reading

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Citations

Jun 16, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Viviana MorosoJaap Kwekkeboom
Jul 1, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Rajalingam, H M Gebel
Apr 5, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J R GreenlandR Rajalingam
Nov 2, 2018·Thorax·Daniel R CalabreseJohn R Greenland

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