Variable interval schedules of timeout from avoidance: effects of ethanol, naltrexone, and CGS 8216

Pharmacology, Biochemistry, and Behavior
M GalizioB A Spencer

Abstract

Four rats were trained on concurrent schedules of shock avoidance and timeout from avoidance, where responses on one lever postponed shock and responses on another lever occasionally (VI 45 sec schedule) produced a 2-min timeout during which the avoidance schedule was suspended. These procedures maintained stable rates of responding on both levers, providing a baseline for studying the effects of drugs on behavior under different types of aversive control (shock avoidance and timeout from avoidance). In the first experiment the effects of ethanol (0.5, 1.0, 1.5, and 2.0 g/kg) and an opiate antagonist, naltrexone (1 mg/kg) were assessed alone and in combination. Ethanol produced a dose-dependent decrease in avoidance characterized by increased shock rates and decreased response rates. At the same time, however, responding on the timeout lever generally increased relative to avoidance lever rates. All of these effects were largely confined to the early parts of the 2-hr session, when blood-ethanol levels were relatively high. Naltrexone had no effect on performances and did not interact with ethanol. In a second experiment, the effects of the benzodiazepine antagonist CGS 8216 were studied alone, and in combination with ethanol. ...Continue Reading

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Citations

Nov 1, 1989·Pharmacology, Biochemistry, and Behavior·M Galizio
Oct 1, 1990·Pharmacology, Biochemistry, and Behavior·M GalizioJ A Welker
Nov 1, 1987·Peptides·G A OlsonA J Kastin
Sep 1, 1991·Journal of the Experimental Analysis of Behavior·M Galizio, A R Allen
Jan 1, 1995·Journal of the Experimental Analysis of Behavior·M Galizio, M O Liborio
May 1, 1994·Journal of the Experimental Analysis of Behavior·F van Haaren, T J Zarcone
Jan 1, 1987·Journal of the Experimental Analysis of Behavior·M Perone, M Galizio
Nov 13, 2012·Journal of the Experimental Analysis of Behavior·Chad M GaluskaMichael Perone
Jan 1, 1987·Journal of the Experimental Analysis of Behavior·M Galizio, M Perone
Nov 1, 1992·Journal of the Experimental Analysis of Behavior·K Courtney, M Perone

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