PMID: 7372519Mar 1, 1980Paper

Variable open-loop gain in the control of thermogenesis in cold-exposed rabbits

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
J T Stitt

Abstract

We have previously demonstrated a multiplicative interaction between mean skin temperature (Tsk) and hypothalamic temperature (Thy) in the control of thermogenesis in cold exposed rabbits. Such a model predicts that open-loop gain will not be constant, but will vary according to the direction and degree of Thy displacements and to the prevailing level of Tsk when Thy is altered. Open-loop gain was calculated from steady-state displacements in body temperature induced by sustained step displacements in Thy. Hypothalamic temperature of rabbits was clamped at various levels ranging from 2 degrees C above to 3 degrees C below normal Thy and the resulting changes in rectal temperature attained at steady state were recorded. Experiments were conducted at ambient temperatures (Ta) of 2 degrees and 15 degrees C. Open-loop gain in response to hypothalamic heating was always greater than that obtained in response to equivalent levels of hypothalamic cooling. Furthermore, at lower levels of Tsk (Ta = 2 degrees C) open-loop gain was greater for all levels of Thy displacement when compared to that measured at higher levels of Tsk (Ta = 15 degrees C).

Citations

Aug 1, 1992·Acta Physiologica Scandinavica·H P Bergland, J B Mercer
Jan 1, 1984·Biological cybernetics·R GraenerM Buse
Sep 1, 1987·Acta Physiologica Scandinavica·J B Mercer, E Simon

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