PMID: 8580632Nov 1, 1995Paper

Variable oxygenation response to inhaled nitric oxide in severe persistent pulmonary hypertension of the newborn

Acta Paediatrica
R TurbowM Hallman

Abstract

The causes of variable responsiveness to inhaled nitric oxide (NO) in Persistent Pulmonary Hypertension of the Newborn (PPHN) are unknown. The changes in the severity of respiratory failure after the onset of inhaled NO (maximal dose 20 ppm) were studied in 13 consecutive neonates with severe PPHN. Response was defined as a sustained decrease of alveolar-arterial oxygen gradient (AaDO2) by > 20%, or a decrease in oxygenation index (OI) by > 40%. Six neonates had a rapid response within 30 min, three had an intermediate response within 8 h, and three had a delayed response within 12 h after the onset of NO. Three infants with birth asphyxia responded rapidly to inhaled NO. One infant with sepsis did not respond, and two with suspected sepsis had a delayed response. The infants with Meconium Aspiration Syndrome and idiopathic PPHN had a variable response time. Twelve neonates required 4 to 14 days of mechanical ventilation and survived. Infants with PPHN may benefit from a trial of inhaled NO therapy that exceeds 30 min. The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.

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Citations

Feb 20, 1997·Early Human Development·R H Mupanemunda
Feb 24, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·N YamaguchiR Higuchi
Oct 23, 1997·Critical Care Medicine·K Rais-BahramiB L Short
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·K Rais-BahramiB L Short
Jun 10, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·E Gastiasoro-CuestaA Valls-i-Soler
Nov 1, 1996·Acta Paediatrica·D TrevisanutoV Zanardo
Oct 22, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Adel MohamedPatrick J McNamara
Jun 14, 2006·Journal of Critical Care·Patrick J McNamaraHilary E Whyte
Nov 18, 2000·Revista do Hospital das Clínicas·C A OliveiraC R Pereira
Feb 21, 2004·Neonatal Network : NN·Leslie J WilliamsJay S Greenspan
Feb 25, 1998·Pediatric Research·E G CuestaA Valls i Soler

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