Variable oxytocin levels in humans with different degrees of obesity and impact of gastric bypass surgery

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Zoltan PatakyJordi Altirriba

Abstract

Exogenous oxytocin administration in obese mice, rats, and monkeys was shown to induce sustained weight loss, mostly due to a decrease in fat mass, accompanied by an improvement of glucose metabolism. A pilot study in obese humans confirmed the weight-reducing effect of oxytocin. Knowledge about circulating oxytocin levels in human obesity might help indicating which obese subjects could potentially benefit from an oxytocin treatment. Conclusive results on this topic are missing. The aim of this study was to measure circulating oxytocin levels in lean (n = 37) and obese (n = 72) individuals across a wide range of body mass index (BMI) values (18.5-60 kg/m2) and to determine the impact of pronounced body weight loss following gastric bypass surgery in 12 morbidly obese patients. We observed that oxytocin levels were unchanged in overweight and in class I and II obese subjects and only morbidly obese patients (obesity class III, BMI > 40 kg/m2) exhibited significantly higher levels than lean individuals, with no modification 1 year after gastric bypass surgery, despite substantial body weight loss. In conclusion, morbidly obese subjects present elevated oxytocin levels which were unaltered following pronounced weight loss.

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Citations

Oct 28, 2019·Journal of Neuroendocrinology·Elizabeth A LawsonJames E Blevins
Jul 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Mark Florian Joachim WeingartenAnke Tönjes
Jul 25, 2021·International Journal of Molecular Sciences·Liya Kerem, Elizabeth A Lawson

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Methods Mentioned

BETA
gastric bypass
ELISA

Software Mentioned

Power
GraphPad Prism
R
SPSS

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