Variable patterned pudendal nerve stimuli improves reflex bladder activation.

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Tim M BrunsKenneth J Gustafson

Abstract

We evaluated variable patterns of pudendal nerve (PN) stimuli for reflex bladder excitation. Reflex activation of the bladder has been demonstrated previously with 20-33 Hz continuous stimulation of PN afferents. Neuronal circuits accessed by afferent mediated pathways may respond better to physiological patterned stimuli than continuous stimulation. Unilateral PN nerve cuffs were placed in neurologically intact male cats. PN stimulation (0.5-100 Hz) was performed under isovolumetric conditions at bladder volumes up to the occurrence of distension evoked reflex contractions. Stimulus evoked reflex bladder contractions were elicited in eight cats. Across all experiments, bursting of 2-10 pulses at 100-200 Hz repeated at continuous stimulation frequencies evoked significantly larger bladder responses than continuous (single pulse) stimulation (52.0+/-44.5%). Bladder excitation was also effective at 1 Hz continuous stimuli, which is lower than typically reported. Variable patterned pulse bursting resulted in greater evoked reflex bladder pressures and increased the potential stimulation parameter space for effective bladder excitation. Improved bladder excitation should increase the efficacy of neuroprostheses for bladder control.

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Citations

Jul 4, 2013·The Journal of Spinal Cord Medicine·Jennifer L CollingerDouglas J Weber
Mar 13, 2016·Journal of Computational Neuroscience·Meredith J McGee, Warren M Grill
Mar 5, 2009·Neurourology and Urodynamics·Tim M BrunsKenneth J Gustafson
Jul 7, 2015·Neurourology and Urodynamics·Meredith J McGee, Warren M Grill
Mar 1, 2011·Archives of Physical Medicine and Rehabilitation·Denise G TateAmie B Jackson
Jan 15, 2015·The Journal of Spinal Cord Medicine·Meredith J McGeeWarren M Grill
Jan 28, 2014·Neurourology and Urodynamics·Tim M BrunsRobert A Gaunt
Nov 7, 2008·Journal of Biomaterials Applications·Anthony V CaparsoJoseph M Mansour
Oct 17, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Indie C RiceTim M Bruns
Feb 7, 2019·Physiology·Charles C HornLee E Fisher
Nov 11, 2009·Journal of Neural Engineering·Tim M BrunsKenneth J Gustafson
Aug 17, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Dennis BourbeauKenneth Gustafson

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