PMID: 8613412Nov 1, 1995Paper

Variable response of the Mongolian gerbil to unilateral carotid occlusion: magnetic resonance imaging and neuropathological characterization

Italian Journal of Neurological Sciences
G P PelliccioliM V Ambrosini

Abstract

In the present investigation, we estimated both the evolution and the severity of ischemic damage following unilateral carotid occlusion (UCO) in Mongolian gerbils by using conventional magnetic resonance imaging (MRI, i.e. T2 weighted imaging) and histological techniques. Immediately after UCO, the animals showed different clinical effects. The mortality (46%) detected within the first 48h was considered an "stroke-sensitivity", the "stroke-resistant" animals showed wide variability in terms of both temporal evolution and the extent of ischemic damage. The signal hyperintensity and negative MRI observed during the first 30h after UCO did not always correlate with the cerebral damage presented after 14 days, although a close correlation was established between the T2 weighted images taken more than 30h after UCO and neuropathology: the gerbils negative to imaging showed no morphological changes, whereas an enhanced signal was always prognostic of ischemic injury. Moreover, late MRI documented ventricular dilatation. Histopathology showed that the ischemic damage differed among the stroke-resistant gerbils and was often bilateral. The present study confirms the differences in gerbil susceptibility to hemispheric infarction after...Continue Reading

References

Mar 1, 1992·Journal of the Neurological Sciences·K HabaA Mori
Nov 1, 1992·Stroke; a Journal of Cerebral Circulation·J A OostveenL R Williams
Nov 1, 1992·Stroke; a Journal of Cerebral Circulation·A L BuszaD G Gadian
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·K MinematsuM Fisher
Jun 1, 1992·Stroke; a Journal of Cerebral Circulation·C Millikan
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund
Jun 1, 1991·Stroke; a Journal of Cerebral Circulation·R A KnightD Peck
May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M E MoseleyP R Weinstein
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J DeLeoG W Kreutzberg
Mar 1, 1986·Radiology·M T McNamaraR C Brasch
Feb 1, 1993·Stroke; a Journal of Cerebral Circulation·T KudoT Nishimura

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Citations

Jun 1, 1996·Italian Journal of Neurological Sciences·C GambelungheM V Ambrosini

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