Variable selection strategies and its importance in clinical prediction modelling

Family Medicine and Community Health
Mohammad Ziaul Islam Chowdhury, Tanvir C Turin

Abstract

Clinical prediction models are used frequently in clinical practice to identify patients who are at risk of developing an adverse outcome so that preventive measures can be initiated. A prediction model can be developed in a number of ways; however, an appropriate variable selection strategy needs to be followed in all cases. Our purpose is to introduce readers to the concept of variable selection in prediction modelling, including the importance of variable selection and variable reduction strategies. We will discuss the various variable selection techniques that can be applied during prediction model building (backward elimination, forward selection, stepwise selection and all possible subset selection), and the stopping rule/selection criteria in variable selection (p values, Akaike information criterion, Bayesian information criterion and Mallows' Cp statistic). This paper focuses on the importance of including appropriate variables, following the proper steps, and adopting the proper methods when selecting variables for prediction models.

References

Apr 1, 1984·Statistics in Medicine·F E HarrellR A Rosati
Dec 1, 1996·Journal of Clinical Epidemiology·P PeduzziA R Feinstein
Dec 22, 2006·American Journal of Epidemiology·Eric Vittinghoff, Charles E McCulloch
Apr 2, 2009·BMJ : British Medical Journal·Patrick RoystonYvonne Vergouwe
Jul 9, 2010·Journal of Human Hypertension·K-L ChienY-T Lee
Oct 30, 2010·The Journal of Clinical Hypertension·Abhijit V KshirsagarHeejung Bang
Jun 5, 2012·Journal of the American Medical Informatics Association : JAMIA·Richard J HoldenBen-Tzion Karsh
May 9, 2014·Ecology·Ken AhoTeri Peterson
Jun 6, 2014·European Heart Journal·Ewout W Steyerberg, Yvonne Vergouwe
Mar 12, 2016·Journal of Clinical Epidemiology·Emmanuel O OgundimuGary S Collins
Mar 22, 2016·Endocrinology and Metabolism·Yong Ho LeeDae Jung Kim

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Citations

Jan 28, 2021·International Journal of Environmental Research and Public Health·Maria M JohanssonHuan-Ji Dong
Mar 9, 2021·Critical Care Research and Practice·Osaree AkaraborwornKomet Thongkhao
Mar 31, 2021·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Philippa Nelson, Rachael Nugent
Apr 8, 2021·Journal of Thrombosis and Haemostasis : JTH·Ganeem K JunejaUNKNOWN COVID-BEACONS investigators
May 5, 2021·Journal of Psychosomatic Obstetrics and Gynaecology·Vahideh BehmardNasrin Bahri
May 25, 2021·Journal of the International Neuropsychological Society : JINS·Wobbie van den HurkAnders Gustavsson
Jul 16, 2021·Frontiers in Psychiatry·Thiago Blanco-VieiraMaria Conceição do Rosário
Jul 17, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Paula AranazJose I Riezu-Boj
Aug 6, 2021·Journal of Parasitology Research·Pie NtampakaGervais Habarugira
Aug 20, 2021·Frontiers in Aging Neuroscience·Jessica M CollinsJames C Vickers
Sep 2, 2021·Infectious Disease Modelling·Nurmarni Athirah Abdul WahidHaliza Abd Rahman
Oct 29, 2021·Psychology and Psychotherapy·Sarah J HamiltonAnalise O'Donovan

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Software Mentioned

BariWound
AIC

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