Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.

Molecular Biology and Evolution
Duong T NguyenWeilong Hao

Abstract

Mutation and recombination are the primary sources of genetic variation. To better understand the evolution of genetic variation, it is crucial to comprehensively investigate the processes involving mutation accumulation and recombination. In this study, we performed mutation accumulation experiments on four heterozygous diploid yeast species in the Saccharomycodaceae family to determine spontaneous mutation rates, mutation spectra, and losses of heterozygosity (LOH). We observed substantial variation in mutation rates and mutation spectra. We also observed high LOH rates (1.65-11.07×10-6 events per heterozygous site per cell division). Biases in spontaneous mutation and LOH together with selection ultimately shape the variable genome-wide nucleotide landscape in yeast species.

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J W Drake
Feb 1, 1988·Human Genetics·D N Cooper, H Youssoufian
Sep 1, 1974·Genetics·J M Smith
Jul 30, 1974·Biochemistry·T Lindahl, B Nyberg
Feb 13, 2003·Nucleic Acids Research·Sean PalmerJac A Nickoloff
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Geraldine ButlerKenneth H Wolfe
Dec 1, 2004·Annual Review of Genetics·Berit Olsen Krogh, Lorraine S Symington
Mar 21, 2006·Trends in Biochemical Sciences·Miguel Garcia-Diaz, Thomas A Kunkel
Aug 25, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Knop
Nov 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Angela R OmilianMichael Lynch
Jun 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael LynchW Kelley Thomas
Aug 22, 2008·PLoS Biology·Cathy Haag-LiautardPeter D Keightley
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Mar 25, 2010·Genome Biology and Evolution·Dana K HoweDee R Denver
Jun 19, 2010·Nature Reviews. Genetics·Bernard Dujon
Sep 15, 2010·PLoS Genetics·Ruth Hershberg, Dmitri A Petrov
Jan 12, 2011·Nature Biotechnology·James T RobinsonJill P Mesirov
Aug 9, 2011·Genome Biology and Evolution·Michael Lynch
Nov 22, 2011·BMC Bioinformatics·Frazer MeachamLior Pachter
Mar 3, 2012·G3 : Genes - Genomes - Genetics·Wenjun LiJoseph Heitman
Mar 23, 2012·Genome Biology and Evolution·Dee R DenverCharles F Baer
Apr 18, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Anton BankevichPavel A Pevzner
May 26, 2012·Genome Biology and Evolution·Eugénie PessiaGabriel A B Marais
Sep 19, 2012·BMC Bioinformatics·Estelle Proux-WéraKenneth H Wolfe
Mar 12, 2013·Genome Biology and Evolution·Laura E Williams, Jennifer J Wernegreen
Apr 9, 2013·Nature Biotechnology·Sebastian JünemannDag Harmsen
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
May 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yuan O ZhuDmitri A Petrov
Nov 6, 2014·Molecular Biology and Evolution·Peter D KeightleyChris D Jiggins
Nov 9, 2014·Genetics·Lorraine S SymingtonMichael Lisby
Nov 27, 2014·Genome Medicine·Han FangGholson J Lyon
Mar 10, 2015·Molecular Biology and Evolution·Way SungMichael Lynch

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Citations

Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yang SuiThomas D Petes
Apr 2, 2021·Marine Life Science & Technology·Jiao PanHongan Long
Oct 9, 2021·Nature Communications·Michael HabigEva H Stukenbrock
Nov 5, 2021·Genome Biology·Ioannis A PapaioannouMichael Knop

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