Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex

Cerebral Cortex
Anna PitasMiguel Maravall

Abstract

Making sense of the world requires distinguishing temporal patterns and sequences lasting hundreds of milliseconds or more. How cortical circuits integrate over time to represent specific sensory sequences remains elusive. Here we assessed whether neurons in the barrel cortex (BC) integrate information about temporal patterns of whisker movements. We performed cell-attached recordings in anesthetized mice while delivering whisker deflections at variable intervals and compared the information carried by neurons about the latest interstimulus interval (reflecting sensitivity to instantaneous frequency) and earlier intervals (reflecting integration over timescales up to several hundred milliseconds). Neurons carried more information about the latest interval than earlier ones. The amount of temporal integration varied with neuronal responsiveness and with the cortical depth of the recording site, that is, with laminar location. A subset of neurons in the upper layers displayed the strongest integration. Highly responsive neurons in the deeper layers encoded the latest interval but integrated particularly weakly. Under these conditions, BC neurons act primarily as encoders of current stimulation parameters; however, our results sug...Continue Reading

References

May 22, 2001·Journal of Computational Neuroscience·A Borst, J Haag
Aug 24, 2001·Nature·A L FairhallR R de Ruyter Van Steveninck
Jul 7, 2007·Journal of Neurophysiology·Stefano PanzeriRasmus S Petersen
Nov 8, 2008·Somatosensory & Motor Research·Ernest E Kwegyir-AffulDaniel J Simons
Dec 26, 2008·Journal of Neurophysiology·V KhatriH P Zeigler
Jan 16, 2009·Nature Reviews. Neuroscience·Dean V Buonomano, Wolfgang Maass
Jul 31, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bruce A Carlson
Dec 23, 2009·PLoS Biology·Danko NikolićWolfgang Maass
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maik C Stüttgen, Cornelius Schwarz
Apr 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian Nils LundstromMiguel Maravall
Aug 14, 2010·Science·Tiago BrancoMichael Häusser
Nov 26, 2010·Nature Neuroscience·Qi WangGarrett B Stanley
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew A GeorgeBruce A Carlson
Jun 5, 2012·Cerebral Cortex·Toshio Miyashita, Daniel E Feldman
Jun 15, 2012·Journal of Neurophysiology·Stefan KlampflWolfgang Maass
Nov 20, 2012·Nature Neuroscience·Luc EstebanezDaniel E Shulz
Dec 1, 2012·Progress in Neurobiology·Dirk FeldmeyerCornelius Schwarz
Apr 9, 2013·Nature Neuroscience·Knarik BagdasarianEhud Ahissar
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shreejoy J TripathyNathaniel N Urban
Nov 10, 2013·Nature·Kenneth D Harris, Thomas D Mrsic-Flogel
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen V David, Shihab A Shamma
Dec 24, 2013·Neuron·Zengcai V GuoKarel Svoboda
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marta Díaz-QuesadaMiguel Maravall
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Arash FassihiMathew E Diamond
Feb 20, 2014·Current Opinion in Neurobiology·Miguel Maravall, Mathew E Diamond
Mar 31, 2015·Nature Neuroscience·François P ChabrolDavid A DiGregorio
Apr 17, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael R BaleRasmus S Petersen
Aug 8, 2015·ELife·Samuel Andrew HiresKarel Svoboda

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Citations

May 21, 2016·Frontiers in Neural Circuits·Alexander Naka, Hillel Adesnik
Aug 17, 2017·ELife·Michael R BaleMiguel Maravall
Jun 9, 2020·Frontiers in Neuroscience·Richard M VickeryIngvars Birznieks

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