Variable temporal sampling and tube current modulation for myocardial blood flow estimation from dose-reduced dynamic computed tomography

Journal of Medical Imaging
Dimple ModgilPatrick J La Riviere

Abstract

Quantification of myocardial blood flow (MBF) can aid in the diagnosis and treatment of coronary artery disease. However, there are no widely accepted clinical methods for estimating MBF. Dynamic cardiac perfusion computed tomography (CT) holds the promise of providing a quick and easy method to measure MBF quantitatively. However, the need for repeated scans can potentially result in a high patient radiation dose, limiting the clinical acceptance of this approach. In our previous work, we explored techniques to reduce the patient dose by either uniformly reducing the tube current or by uniformly reducing the number of temporal frames in the dynamic CT sequence. These dose reduction techniques result in noisy time-attenuation curves (TACs), which can give rise to significant errors in MBF estimation. We seek to investigate whether nonuniformly varying the tube current and/or sampling intervals can yield more accurate MBF estimates for a given dose. Specifically, we try to minimize the dose and obtain the most accurate MBF estimate by addressing the following questions: when in the TAC should the CT data be collected and at what tube current(s)? We hypothesize that increasing the sampling rate and/or tube current during the time...Continue Reading

References

Aug 1, 1985·Physics in Medicine and Biology·R L Siddon
Apr 3, 2001·Cardiovascular Research·P ChareonthaitaweeP G Camici
Nov 17, 2007·Investigative Radiology·Richard T GeorgeAlbert C Lardo
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Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo G Camici, Ornella E Rimoldi
Mar 13, 2014·Physics in Medicine and Biology·Michael BindschadlerAdam M Alessio
Feb 3, 2015·Journal of Medical Imaging·Dimple ModgilPatrick J La Rivière

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