Variable Ventilation Improved Respiratory System Mechanics and Ameliorated Pulmonary Damage in a Rat Model of Lung Ischemia-Reperfusion

Frontiers in Physiology
André Soluri-MartinsPatricia R M Rocco

Abstract

Lung ischemia-reperfusion injury remains a major complication after lung transplantation. Variable ventilation (VV) has been shown to improve respiratory function and reduce pulmonary histological damage compared to protective volume-controlled ventilation (VCV) in different models of lung injury induced by endotoxin, surfactant depletion by saline lavage, and hydrochloric acid. However, no study has compared the biological impact of VV vs. VCV in lung ischemia-reperfusion injury, which has a complex pathophysiology different from that of other experimental models. Thirty-six animals were randomly assigned to one of two groups: (1) ischemia-reperfusion (IR), in which the left pulmonary hilum was completely occluded and released after 30 min; and (2) Sham, in which animals underwent the same surgical manipulation but without hilar clamping. Immediately after surgery, the left (IR-injured) and right (contralateral) lungs from 6 animals per group were removed, and served as non-ventilated group (NV) for molecular biology analysis. IR and Sham groups were further randomized to one of two ventilation strategies: VCV (n = 6/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 2 cmH2O, fraction of inspired ox...Continue Reading

References

Feb 1, 1992·Journal of Applied Physiology·R PalazzoD P Schuster
Feb 1, 1992·Journal of Applied Physiology·A HamvasD P Schuster
Aug 1, 1991·The Journal of Clinical Investigation·A B FisherR G Eckenhoff
Jan 1, 1990·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·M J JurmannA Haverich
Feb 11, 1988·Nature·J B Lansman
Jul 1, 1988·Journal of Applied Physiology·M J TobinM A Sackner
Jul 1, 1996·The Annals of Thoracic Surgery·R J NovickJ Lee
Feb 15, 1996·The Journal of Surgical Research·R R GilmontR S Rees
Nov 5, 1997·Biochemical and Biophysical Research Communications·M SuzukiM Sokabe
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·W A MutchG R Lefevre
Dec 21, 2002·American Journal of Respiratory and Critical Care Medicine·Paolo PelosiLuciano Gattinoni
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
Jul 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen P AroldEdward P Ingenito
Jan 15, 2005·Journal of Applied Physiology·Sara L S MenezesPatricia R M Rocco
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Mar 15, 2008·Journal of Applied Physiology·Apiradee ThammanomaiBéla Suki
May 23, 2008·Critical Care Medicine·Douglas R RivaPatricia R M Rocco
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Oct 25, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Stefano SalisErminio Sisillo
Jan 10, 2009·Proceedings of the American Thoracic Society·Carlos Henrique R BoasquevisqueShaf Keshavjee
Jan 13, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen P AroldBéla Suki
Jan 20, 2009·American Journal of Respiratory and Critical Care Medicine·Peter M SpiethMarcelo Gama de Abreu
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Willem A den HengstAn L Moens
Mar 5, 2011·Journal of Applied Physiology·Baoshun MaJason H T Bates
May 3, 2011·American Journal of Respiratory Cell and Molecular Biology·Gustavo Matute-BelloUNKNOWN Acute Lung Injury in Animals Study Group
Apr 3, 2012·Anesthesia and Analgesia·Alysson Roncally CarvalhoAntonio Giannella-Neto
May 1, 2012·Anesthesia and Analgesia·Alysson Roncally CarvalhoAntonio Giannella-Neto
Sep 3, 2013·Antioxidants & Redox Signaling·Manish MittalAsrar B Malik
Apr 10, 2014·Experimental Lung Research·Robert HuhleMarcelo Gama de Abreu
Nov 2, 2014·The European Respiratory Journal·Keith C MeyerUNKNOWN ISHLT/ATS/ERS BOS Task Force Committee

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Methods Mentioned

BETA
lavage
electron microscopy
PCR

Software Mentioned

Power
GraphPad
LabVIEW®
GraphPad Prism

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