Variables associated with patient-reported outcomes in patients with myeloproliferative neoplasms.

Leukemia & Lymphoma
Dayu ShiQian Jiang

Abstract

We explored variables associated with patient-reported outcomes (PROs) including symptom burden, impact on daily life and work, obstacles during therapy, satisfaction level with therapy, and health-related quality of life in 1500 respondents with myeloproliferative neoplasms (MPNs) including essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF) in a multicenter, cross-sectional study across China, a representative of the developing countries. In multivariate analyses, urban household registration and higher education level were significantly-associated with no symptoms at diagnosis in respondents with ET or MF. CALR mutation was significantly-associated with lower MPN-10 scores in respondents with MF. Higher MPN-10 scores were significantly-associated with negative impact on daily life and work as well as lower satisfaction level in respondents with ET, PV and MF. Receiving ruxolitinib was significantly-associated with high satisfaction and satisfaction in respondents with MF. In addition, other demographics and clinical variables were also impacting PROs.

References

Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Naseema GangatAyalew Tefferi
Jul 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tiziano BarbuiAyalew Tefferi
Mar 2, 2012·The New England Journal of Medicine·Claire HarrisonGiovanni Barosi
Mar 2, 2012·The New England Journal of Medicine·Srdan VerstovsekHagop M Kantarjian
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robyn M EmanuelRuben A Mesa
Aug 21, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manali I PatelHeather A Wakelee
Jul 6, 2014·Blood·Elisa RumiUNKNOWN Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators
Feb 12, 2015·BMJ : British Medical Journal·Eugene C NelsonStaffan Lindblad
Mar 18, 2015·Thyroid : Official Journal of the American Thyroid Association·Theresa H M KeeganPamela L Horn-Ross
Aug 23, 2017·Leukemia & Lymphoma·Yasser H ElNahassWafaa H ElMetnawy
Sep 25, 2017·Current Hematologic Malignancy Reports·Holly Geyer, Ruben A Mesa

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.