Variables Contributing to Thyroid (Dys)Function in Pregnant Women: More than Thyroid Antibodies?

European Thyroid Journal
Flora Veltri, Kris Poppe

Abstract

Variability in thyroid function in pregnant women is the result of 2 main determinants, each accounting for approximately half of it. The first is the genetically determined part of which the knowledge increases fast, but most remains to be discovered. The second determinant is caused by an ensemble of variables of which thyroid autoimmunity is the best known, but also by others such as parity, smoking, age, and BMI. More recently, new candidate variables have been proposed, such as iron, endocrine disruptors, and the ethnicity of the pregnant women. In the future, the diagnosis and treatment of thyroid (dys)function may be optimized by the use of each individual's pituitary-thyroid set point, corrected with a factor taking into account the impact of nongenetically determined variables.

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Citations

Feb 9, 2019·Thyroid : Official Journal of the American Thyroid Association·Stine Linding AndersenPeter Vestergaard
Jan 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Georgiana SitorisKris Poppe
Dec 27, 2019·Clinical Endocrinology·Louise KnøsgaardStine Linding Andersen
Aug 15, 2020·Clinical Endocrinology·Stine Linding AndersenJørn Olsen
Jun 24, 2021·Journal of the Endocrine Society·Line SletnerSara Salehi Hammerstad

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