Variance and Scale-Free Properties of Resting-State Blood Oxygenation Level-Dependent Signal After Fear Memory Acquisition and Extinction

Frontiers in Human Neuroscience
Alina TeterevaOlga Martynova

Abstract

Recently, the dynamic properties of brain activity rather than its stationary values have attracted more interest in clinical applications. It has been shown that brain signals exhibit scale-free dynamics or long-range temporal correlations (LRTC) that differ between rest and cognitive tasks in healthy controls and clinical groups. Little is known about how fear-inducing tasks may influence dispersion and the LRTC of subsequent resting-state brain activity. In this study, we aimed to explore the changes in the variance and scale-free properties of the brain's blood oxygenation level-dependent (BOLD) signal during the resting-state sessions before and after fear learning and fear memory extinction. During a 1-h break between magnetic resonance imaging (MRI) scanning, 23 healthy, right-handed volunteers experienced a fear extinction procedure, followed by Pavlovian fear conditioning that included partial reinforcement using mild electrical stimulation. We extracted the average time course of the BOLD signal from 245 regions of interest (ROIs) taken from the resting-state functional atlas. The variance of the BOLD signal and the Hurst exponent (H), which reflects the scale-free dynamic, were compared in the resting states before a...Continue Reading

References

Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Feb 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·C K PengA L Goldberger
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·J B PochonB Dubois
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Feb 18, 2004·IEEE Transactions on Medical Imaging·Christian F Beckmann, Stephen M Smith
Oct 27, 2004·NeuroImage·Ed BullmoreMichael Breakspear
Mar 1, 2005·NeuroImage·Voichiţa MaximEd Bullmore
Feb 7, 2008·IEEE Transactions on Neural Networks·A Hyvärinen
May 6, 2008·Human Brain Mapping·Eugene P DuffGary F Egan
Aug 16, 2008·Journal of Neuroscience Methods·John SucklingEdward Bullmore
Jan 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory R Samanez-LarkinBrian Knutson
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Douglas D GarrettCheryl L Grady
Sep 6, 2011·NeuroImage·Tim HahnAndreas J Fallgatter
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Biyu J He
Nov 22, 2011·Frontiers in Psychiatry·Christine A RabinakK Luan Phan
Jun 21, 2012·Frontiers in Physiology·P CiuciuA Kleinschmidt
Sep 1, 2012·Frontiers in Human Neuroscience·Douglas H SchultzFred J Helmstetter
Dec 12, 2012·Frontiers in Physiology·Richard HardstoneKlaus Linkenkaer-Hansen
Mar 6, 2013·Neuroscience and Biobehavioral Reviews·Douglas D GarrettCheryl L Grady
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Enzo TagliazucchiHelmut Laufs
Sep 7, 2013·Brain Imaging and Behavior·Cheryl L Grady, Douglas D Garrett
Jan 15, 2014·Neuron·Emmanuelle Tognoli, J A Scott Kelso
May 16, 2014·PloS One·Moses O SokunbiRoger T Staff
Mar 17, 2015·NeuroImage·Raimon H R PruimChristian F Beckmann
Mar 19, 2015·Frontiers in Systems Neuroscience·Shruti JapeeLeslie G Ungerleider
May 28, 2016·Cerebral Cortex·Lingzhong FanTianzi Jiang
Dec 19, 2016·NeuroImage·Ludovica GriffantiStephen M Smith
May 6, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason S NomiAaron S Heller

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Software Mentioned

MELODIC
MATLAB Bioinformatics Toolbox
FSL ( FMRIB Software Library
numpy
AROMA
FLIRT FSL
FLIRT
Nolds
FMRIB
Brainnetome

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