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Variance component model to account for sample structure in genome-wide association studies

Nature Genetics

Mar 9, 2010

Hyun Min KangEleazar Eskin

Abstract

Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious associations. Variance component app...read more

Mentioned in this Paper

Genome-Wide Association Study
Quantitative Trait Loci
Genome
Computer Programs and Programming
Genomics
Two-Parameter Models
Tribes
Principal Component Analysis
Single Nucleotide Polymorphism
Phenotype Determination
4
1107
1
Paper Details
References
  • References46
  • Citations634
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  • References46
  • Citations634
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Variance component model to account for sample structure in genome-wide association studies

Nature Genetics

Mar 9, 2010

Hyun Min KangEleazar Eskin

PMID: 20208533

DOI: 10.1038/ng.548

Abstract

Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious associations. Variance component app...read more

Mentioned in this Paper

Genome-Wide Association Study
Quantitative Trait Loci
Genome
Computer Programs and Programming
Genomics
Two-Parameter Models
Tribes
Principal Component Analysis
Single Nucleotide Polymorphism
Phenotype Determination
4
1107
1

Related Papers

Paper Details
References
  • References46
  • Citations634
12345
  • References46
  • Citations634
12345...
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