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Variance component model to account for sample structure in genome-wide association studies

Nature Genetics

Apr 1, 2010

Hyun Min KangEleazar Eskin

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Abstract

Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious associations. Variance component app...read more

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    • References41
    • Citations540
    • References41
    • Citations540
  • Variance component model to account for sample structure in genome-wide association studies

    Nature Genetics

    Apr 1, 2010

    Hyun Min KangEleazar Eskin

    PMID: 20208533

    DOI: 10.1038/ng.548

    Abstract

    Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious associations. Variance component app...read more

    4
    1057
    1

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    • Citations540
    • References41
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