Variance of the global signal as a pretreatment predictor of antidepressant treatment response in drug-naïve major depressive disorder

Brain Imaging and Behavior
Jiajia ZhuYongqiang Yu

Abstract

Several behavioral and neuroimaging markers could be used to predict eventual antidepressant medication (ADM) outcomes in patients with major depressive disorder (MDD). However, these predictors are either subjective or complex, which has limited their clinical use. Thus, we aimed to identify an objective and easy-to-get marker to predict early therapeutic efficacy. Forty-seven drug-naïve patients with MDD and 47 age-, gender- and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) scans. We calculated the variable coefficient (VC) of the global signal for each subject. Baseline Hamilton Rating Scale for Depression (HRSD) score and that after 2 weeks of ADM were assessed for patients. Although there was no difference in VC between patients with MDD and healthy controls, we found a significant positive correlation between the VC and the decline rate of HRSD scores in the patients. Compared with the non-responding depression (NRD) group, the treatment-responsive depression (TRD) group had a higher VC. Receiver operator characteristic curve analysis revealed that the VC exhibited a good ability to differentiate TRD from NRD. In addition, the linear and logistic regression analyse...Continue Reading

References

Aug 1, 1988·Archives of General Psychiatry·J B Williams
Dec 24, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·P M LewinsohnD N Klein
Nov 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin M KatzAlan Frazer
Apr 28, 2004·NeuroImage·Paul M MaceyRonald M Harper
May 5, 2004·The British Journal of Psychiatry : the Journal of Mental Science·T B UstünC J L Murray
Oct 27, 2004·NeuroImage·Richard B BuxtonThomas T Liu
Dec 14, 2004·Journal of Psychiatric Research·Stephen K BrannanGary D Tollefson
Oct 14, 2008·Journal of Affective Disorders·Dietrich van CalkerElisabeth Schramm
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
Dec 9, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shinichiro NakajimaHiroyuki Uchida
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marieke L SchölvinckDavid A Leopold
Jun 10, 2010·Human Brain Mapping·Jeffrey S AndersonDeborah Yurgelun-Todd
Dec 8, 2010·Archives of General Psychiatry·Steven C Marcus, Mark Olfson
Jul 8, 2011·Nature·Pamela Y CollinsDan J Stein
Sep 6, 2011·NeuroImage·Xiaoqian J ChaiSusan Whitfield-Gabrieli
Feb 16, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gang ChenShi-Jiang Li
Jan 1, 2013·Biological Psychiatry·Baojuan LiDewen Hu
Apr 11, 2013·NeuroImage·Kevin MurphyPeter A Bandettini
Jul 28, 2013·Journal of Affective Disorders·Hitoshi SakuraiMasaru Mimura
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Genevieve J YangAlan Anticevic
Jun 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Erinn S GideonsLisa M Monteggia
Apr 15, 2015·Neuropsychobiology·Johannes BeckEdith Holsboer-Trachsler
Oct 19, 2016·NeuroImage·Jonathan D PowerAlex Martin

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