Variance reduction in a dataset of normal macular ganglion cell plus inner plexiform layer thickness maps with application to glaucoma diagnosis.

Investigative Ophthalmology & Visual Science
Robert W KnightonDonald L Budenz

Abstract

To examine the similarities and differences in the shape of the macular ganglion cell plus inner plexiform layers (GCL+IPL) in a healthy human population, and seek methods to reduce population variance and improve discriminating power. Macular images of the right eyes of 23 healthy subjects were obtained with spectral domain optical coherence tomography. The thickness of GCL+IPL was determined by manual segmentation, areas with blood vessels were removed, and the resulting maps were fit by smooth surfaces in polar coordinates centered on the fovea. The mean GCL+IPL thickness formed a horizontal elliptical annulus. The variance increased toward the center and was highest near the foveal edge. Individual maps differed in foveal size and overall GCL+IPL thickness. Foveal size correction by radially shifting individual maps to the same foveal size as the mean map reduced perifoveal variance. Thickness alignment by shifting individual maps axially, then radially, to match the mean map reduced overall variance. These transformations had very little effect on the population mean. Simple transformations of individual GCL+IPL thickness maps to a canonical form can considerably reduce the population variance in a sample of normal eyes, l...Continue Reading

Citations

Oct 4, 2012·Investigative Ophthalmology & Visual Science·Robert W Knighton, Giovanni Gregori
Apr 15, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Muhammed S AlluwimiVictor E Malinovsky
Mar 19, 2013·Progress in Retinal and Eye Research·Jan M ProvisJoseph Carroll
Aug 15, 2018·Acta Ophthalmologica·Lucas A TorresBalwantray C Chauhan

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