Variant angina pectoris: investigation of indexes of sympathetic nervous system function
One thousand forty-five spontaneous episodes of S-T segment elevation were observed in three patients over a total of 72 days of continuous electrocardiographic monitoring. Eighty-nine percent of episodes were asymptomatic; chest pain tended to occur with episodes longer than 3 minutes, and ventricular ectopy occurred almost exclusively with symptomatic episodes. Nitroglycerin regularly relieved angina or S-T elevation, or both. Plasma and urinary catecholamines and their metabolites were normal. Episodes of variant angina were not associated with a generalized increase in sympathetic outflow because serum catecholamine levels at the onset and termination of the S-T abnormalities were not elevated. Controlled trials of propranolol showed no significant beneficial effect. Propranolol significantly increased the length of episodes of S-T elevation in one patient, increasing ventricular irritability. The overall course of variant angina was quite variable, with spontaneous and long-lasting remissions, necessitating cautions interpretation of clinical trials.
Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion
Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of "preinfarction" angina
Treatment of spontaneous angina pectoris with beta blocking agents. A clinical, electrocardiographic, and haemodynamic appraisal
Prinzmetal's variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm: documentation by coronary arteriography
Left and right heart haemodynamics during spontaneous angina pectoris. Comparison between angina with ST segment depression and angina with ST segment elevation
The evidence for alpha-adrenoceptors in the coronary circulation and their possible relevance to the physiological regulation of myocardial blood flow
Effect of H1 receptor stimulation on coronary artery diameter in patients with variant angina: comparison with effect of acetylcholine
Platelet reactivity and its dependence on alpha-adrenergic receptor function in patients with ischaemic heart disease
Findings from long-term electrocardiographic monitoring of patients with variant angina in a coronary care unit
Detrimental effect of propranolol in patients with coronary arterial spasm countered by combination with diltiazem
Failure of experimental atherosclerosis to sensitize coronary arteries to spasm in hypercholesterolemic rabbits
Induction of polymorphic ventricular tachycardia by programmed ventricular stimulation in vasospastic angina pectoris
Influence of partial sympathetic denervation on the results of myocardial revascularization in variant angina
Reduction of plasma norepinephrine levels in response to brief coronary occlusion in experimental dogs
Noninvasive assessment of the autonomic nervous tone in angina pectoris: an application of digital plethysmography with auditory stimuli
Enhanced peripheral vasoconstrictor response and increased thromboxane A2 synthesis after the cold pressor test in patients with angina at rest
Sympathetic and nonsympathetic neuropeptide Y-containing nerves in the rat myocardium and coronary arteries
Potentiation of coronary vasoconstriction by beta-adrenergic blockade in patients with coronary artery disease
Cardiovascular Diseases: Risk Factors
Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.
Antianginal Drugs: Mechanisms of Action
Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.