PMID: 108989Jun 1, 1979

Variant angina pectoris: investigation of indexes of sympathetic nervous system function

The American Journal of Cardiology
D RobertsonG C Friesinger


One thousand forty-five spontaneous episodes of S-T segment elevation were observed in three patients over a total of 72 days of continuous electrocardiographic monitoring. Eighty-nine percent of episodes were asymptomatic; chest pain tended to occur with episodes longer than 3 minutes, and ventricular ectopy occurred almost exclusively with symptomatic episodes. Nitroglycerin regularly relieved angina or S-T elevation, or both. Plasma and urinary catecholamines and their metabolites were normal. Episodes of variant angina were not associated with a generalized increase in sympathetic outflow because serum catecholamine levels at the onset and termination of the S-T abnormalities were not elevated. Controlled trials of propranolol showed no significant beneficial effect. Propranolol significantly increased the length of episodes of S-T elevation in one patient, increasing ventricular irritability. The overall course of variant angina was quite variable, with spontaneous and long-lasting remissions, necessitating cautions interpretation of clinical trials.


Apr 1, 1978·The American Journal of Cardiology·F A HeuplerW C Sheldon
May 26, 1977·The American Journal of Cardiology·T B BerndtJ S Schroeder
Apr 12, 1973·The New England Journal of Medicine·R N MacAlpin
Sep 1, 1973·Annals of Internal Medicine·M V HermanR Gorlin
Jan 1, 1966·Transactions of the Association of American Physicians·J W Roughgarden
Sep 1, 1971·American Heart Journal·R C RigginsG C Friesinger


Apr 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·C G SobeyO L Woodman
Jan 29, 1988·The American Journal of Cardiology·C J PepineN Norvell
Sep 1, 1984·Journal of the American College of Cardiology·V S Bamrah, G J Schuchard
Jun 1, 1985·Journal of the American College of Cardiology·D RobertsonR M Robertson
Apr 23, 1981·The New England Journal of Medicine·R M RobertsonJ A Oates
Oct 31, 1985·The New England Journal of Medicine·M B FormanR Virmani
Mar 5, 1992·The New England Journal of Medicine·Y Sadovsky, S A Friedman
Nov 1, 1987·Clinical and Experimental Pharmacology & Physiology·O L Woodman
May 1, 1981·British Heart Journal·A L GirottiM B Rosenbaum
Jul 1, 1988·International Journal of Cardiology·L BernardiG Finardi
Sep 1, 1982·The American Journal of Cardiology·A E BuxtonR N Edie
Oct 25, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Samuel Butman
Oct 1, 1983·Journal of the American College of Cardiology·R J Weiss, C B Smith
Feb 1, 1984·The American Journal of Cardiology·M B FormanR M Robertson
Feb 1, 1980·Chest·R K Mautner, G Katz
Jun 1, 1987·Research in Nursing & Health·J Herman
Oct 1, 1980·The American Journal of Cardiology·M E Bertrand
May 1, 1983·Psychophysiology·P Grossman
Jan 1, 1984·Circulation·S ChierchiaA Maseri
Feb 1, 1982·Circulation·Y KoiwayaM Nakamura
Feb 1, 1982·Circulation·R M RobertsonD Robertson
Jul 1, 1981·Circulation·B FreedmanD T Kelly
Dec 1, 1981·Circulation·K YamamotoM Nakamura
Oct 1, 1981·Circulation·S de ServiP Bobba
Aug 26, 1998·Circulation·M SuzukiM Hiraoka
Mar 1, 1981·Clinical Cardiology·R M Robertson, D Robertson
Jan 1, 1981·Catheterization and Cardiovascular Diagnosis·R N Singh
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Jan 1, 1981·Catheterization and Cardiovascular Diagnosis·G BaduiniP F Angelino
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·H Vapaatalo

Related Concepts

Angina Pectoris
Angina Pectoris, Variant
Diastolic Blood Pressure
Structure of Carotid Sinus
Cold Temperature
Water Consumption
Electrocardiographic Recorders
Cardiopulmonary Exercise Test

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