PMID: 11604578Oct 18, 2001Paper

Variant Creutzfeldt-Jakob disease and blood transfusion

Current Opinion in Hematology
M L Turner

Abstract

Variant Creutzfeldt-Jakob disease (vCJD) was first described in the United Kingdom in 1996 and is thought to have been transmitted from cattle infected with bovine spongiform encephalopathy probably via the food chain. Thus far just over 100 definite or probable clinical cases have been described, though the number of people currently infected and the eventual size and geographic distribution of any future clinical epidemic remain uncertain. There is little evidence that sporadic CJD is transmitted by blood transfusion. However, the same cannot necessarily be assumed to apply to the new variant strain of disease in which involvement of peripheral lymphoid tissues has been demonstrated. In the face of uncertainty surrounding the risk of transmission of vCJD by blood products, blood transfusion services in a number of countries have implemented precautionary policies, though whether in the long term these will prove to have been necessary or sufficient remains to be seen.

References

Jun 15, 1991·Lancet·J CollingeA J Dryden
Apr 6, 1996·Lancet·R G WillP G Smith
Jun 27, 1996·Nature·C I LasmézasJ J Hauw
Jan 16, 1997·Nature·S N CousensP G Smith
Mar 20, 1997·Nature·P ParchiH Kretzschmar
Oct 23, 1997·Nature·A F HillP Lantos
Dec 31, 1997·Nature·M A KleinA Aguzzi
May 26, 1998·Biochemical and Biophysical Research Communications·R RubensteinG C Tisone
Jun 5, 1998·Immunology Today·N A MabbottM E Bruce
Jun 23, 1998·The Veterinary Record·B E SchreuderM A Smits
Aug 26, 1998·Lancet·L ManuelidisI Zaitsev
Oct 15, 1998·Nature Medicine·J SafarS B Prusiner
Dec 10, 1998·Nature Medicine·M A KleinA Aguzzi
Jul 28, 1999·The Journal of General Virology·V BeringueD Dormont
Aug 10, 1999·Lancet·J Collinge
Aug 25, 1999·Lancet·R G WillJ W Ironside
Oct 9, 1999·Journal of Virology·R FriggA Aguzzi
Oct 16, 1999·British Journal of Haematology·M Turner
Dec 22, 1999·British Journal of Haematology·G R BarclayM L Turner
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·M R ScottS B Prusiner
Jan 8, 2000·Acta Paediatrica. Supplement·R G Will
Feb 12, 2000·Proceedings. Biological Sciences·A C GhaniR M Anderson
May 11, 2000·Annals of Neurology·R G WillR S Knight
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·J BieschkeH Kretzschmar

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Citations

Apr 8, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·F Boulton
Mar 6, 2003·Vox Sanguinis·C V Prowse, I R MacGregor
Dec 16, 2010·Psychiatry and Clinical Neurosciences·Chih-Wen YangShih-Jung Cheng
Mar 20, 2008·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Karin WurmDagmar Barz
Oct 14, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·J W Ironside, M W Head
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J W Ironside, M W Head
May 26, 2004·Transfusion·Hans Vrielink, Pieter F van der Meer
Aug 26, 2003·The American Journal of Clinical Nutrition·Clare R Trevitt, Pramil N Singh

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