Variant in PNPLA3 is associated with alcoholic liver disease.

Nature Genetics
Chao TianDavid A Hinds

Abstract

Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).

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References

Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hongjin HuangRamsey C Cheung
Jun 15, 2007·American Journal of Human Genetics·Chao TianMichael F Seldin
Mar 20, 2008·American Journal of Physiology. Endocrinology and Metabolism·Margaret Sozio, David W Crabb
Oct 23, 2008·American Journal of Human Genetics·Xin YuanVincent Mooser
Jun 23, 2009·Journal of Medical Genetics·Barbara KolleritsFlorian Kronenberg

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Citations

Jun 2, 2011·Chemical Reviews·Rosalind A Coleman, Douglas G Mashek
May 11, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P OliverA Palou
Aug 10, 2011·Nature Reviews. Gastroenterology & Hepatology·José Altamirano, Ramón Bataller
Mar 6, 2013·Nature Reviews. Gastroenterology & Hepatology·Geoffrey C FarrellShiv Chitturi
Sep 1, 2011·The Journal of Biological Chemistry·Yongcheng HuangHelen H Hobbs
May 7, 2011·Journal of Gastroenterology and Hepatology·Devanshi SethChristopher P Day
Mar 15, 2012·Journal of Gastroenterology and Hepatology·Leon A AdamsCraig E Pennell
Jun 28, 2011·Science·Jonathan C CohenHelen H Hobbs
Oct 2, 2012·The Journal of Clinical Investigation·John Zhong LiHelen H Hobbs
Jan 20, 2011·Journal of Lipid Research·Amanda J HooperJohn R Burnett
Oct 25, 2013·International Journal of Molecular Sciences·Marcin KrawczykFrank Lammert
Nov 17, 2012·World Journal of Gastroenterology : WJG·Silvia Sookoian, Carlos J Pirola
Nov 14, 2013·World Journal of Gastroenterology : WJG·Paola DongiovanniLuca Valenti
May 10, 2012·Gut and Liver·Geoffrey C FarrellShivrakumar Chitturi
Jan 22, 2014·The American Journal of Gastroenterology·Amit G SingalAkbar K Waljee
Jul 30, 2014·Digestive Diseases and Sciences·Sang Soo LeeHyun Young Kim
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yongcheng HuangHelen H Hobbs
Nov 26, 2015·Current Pathobiology Reports·Jun XuTatiana Kisseleva
Nov 6, 2015·Biomolecules·Natalie J Torok
Feb 5, 2016·Alcoholism, Clinical and Experimental Research·Apurva YeluruMack C Mitchell
Feb 3, 2016·The American Journal of Pathology·Richard J W WilkinPhilip N Newsome
Sep 15, 2014·Experimental and Molecular Pathology·Manuela G NeumanSteve Malnick
Oct 31, 2015·Experimental Cell Research·Rotonya M Carr, Rexford S Ahima
Feb 6, 2016·BMC Health Services Research·Julia KöppSebastian Edgar Baumeister
Dec 29, 2015·International Journal of Clinical Practice·V RosatoM Persico
Jun 8, 2015·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Alba BerlangaTeresa Auguet
Jul 28, 2015·Journal of Medical Virology·Kentaro Matsuura, Yasuhito Tanaka
Aug 14, 2012·Clinics and Research in Hepatology and Gastroenterology·Céline DubuquoyMarthe Moldes
Aug 9, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hong-Min NiWen-Xing Ding
Jul 31, 2012·Gastroenterology·Etienne PatinUNKNOWN French ANRS HC EP 26 Genoscan Study Group
Jun 19, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Maria Antonella BurzaStefano Romeo

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