Variant liver estrogen receptor transcripts already occur at an early stage of chronic liver disease

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
E VillaF Manenti

Abstract

Variant estrogen receptors may be found in hepatocellular carcinoma and may influence its natural history. Because it is not known whether their occurrence is an early or a late event during the course of chronic liver disease or whether they cluster in some subgroups of patients, we investigated a series of patients in different stages of chronic liver disease. One hundred eleven consecutive patients were studied for variant estrogen receptor transcripts by reverse-transcription polymerase chain reaction of RNA extracted from liver biopsy specimens. In chronic active hepatitis, variant estrogen receptor transcripts were coexpressed with wild-type significantly more often in men than in women (P = .029) and in hepatitis B surface antigen (HBsAg)-positive subjects than in subjects positive for antibody to hepatitis C virus (P = .0006). In hepatocellular carcinoma, again in men (P = .004) and in HBsAg-positive patients (P = .0015), the variant estrogen receptor transcript was overexpressed or remained the only one expressed. Patients with liver cell dysplasia presented with the same estrogen receptor pattern than patients with hepatocellular carcinoma. This further reinforces the significance of liver cell dysplasia as a preneopl...Continue Reading

References

Nov 1, 1990·Journal of Hepatology·F FarinatiR Naccarato
Feb 8, 1991·Cell·J M NigroB Vogelstein
Apr 1, 1989·Gastroenterology·G P RossiniF Manenti
Jan 1, 1986·Cancer·N NagasueY Ogawa
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S OhnishiM Imawari
Mar 1, 1987·Gastroenterology·L E PorterP K Eagon
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E VillaF Manenti
Jan 1, 1973·The Journal of Pathology·P P Anthony
Sep 1, 1982·The American Journal of Medicine·M A FriedmanP G Hoffman
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriM Ohashi
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jun 1, 1994·Journal of Hepatology·F J Martínez CerezoF Vilardell
Jan 1, 1993·Breast Cancer Research and Treatment·K B Horwitz
Jul 1, 1996·Gastroenterology·E VillaF Manenti
Oct 1, 1996·Gastroenterology·D I Soybel

❮ Previous
Next ❯

Citations

Aug 6, 2002·Molecular and Cellular Endocrinology·Erica VillaFederico Manenti
Aug 6, 2002·Molecular and Cellular Endocrinology·Barbara LeiErica Villa
Aug 6, 2002·Molecular and Cellular Endocrinology·Fabio FarinatiE Villa
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R LeroseE Villa
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E VillaF Manenti
Oct 22, 2008·World Journal of Gastroenterology : WJG·Mamta KalraRashmi Kaul
Apr 9, 2014·Journal of Translational Medicine·Liang ShiXiujun Cai
Dec 17, 2008·Women's Health·Erica Villa
May 26, 2009·European Journal of Gastroenterology & Hepatology·Fabio FarinatiUNKNOWN Italian Liver Cancer group
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Gerald B SharpShoji Tokuoka
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire
Dec 12, 2007·Journal of Viral Hepatitis·F FarinatiR Naccarato
Jun 1, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winnie YeoPaul K S Chan
Apr 3, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ichiro Shimizu, Susumu Ito
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Norie KurahashiUNKNOWN JPHC Study Group
Aug 10, 2013·Cancer Medicine·Shuko HataHironobu Sasano
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hirokazu TakahashiKazuma Fujimoto
Dec 15, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Nsikak J UmohGregory D Kirk
Jan 23, 2015·Journal of Gastroenterology and Hepatology·Seungtaek LimHye Jin Choi
Jan 13, 2006·The American Journal of Gastroenterology·Maria Chiara CantariniUNKNOWN Italian Liver Cancer (ITA.LI.CA) group
Jun 9, 2020·Clinical and Translational Medicine·Hui HuangWei Zou
Apr 16, 2020·International Journal of Environmental Research and Public Health·Paulina KurBarbara Wiszniewska
Mar 19, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Ichiro Shimizu
May 27, 2017·Science China. Life Sciences·Bo ZhengLei Chen
Oct 31, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Xiao-Peng FanKai Wang
Nov 1, 2017·World Journal of Gastroenterology : WJG·Janaki K IyerRashmi Kaul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.