Variant morphology in upper urinary tract urothelial carcinoma: a 14-year case series of biopsy and resection specimens

Human Pathology
Hiroyuki HayashiMuhammad T Idrees

Abstract

Upper urinary tract urothelial carcinoma exhibiting variant morphology, especially in higher-grade tumors, is a recognized phenomenon but has not been comparatively studied in biopsy versus resection material. We studied the morphologic patterns and clinicopathological features, and provide a comparison between biopsy and resection specimens. Consultation cases were evaluated separately to investigate for possible consultation bias. A total of 383 in-house cases from 352 patients including 314 resection specimens and 69 biopsies from 2001 to 2014 were reviewed from a single institution. Histologic type, tumor grade, invasion, pathologic stage, nodal status, metastasis, and the presence and type of variant morphology for each case were evaluated. Variant morphology was identified in 5 biopsy specimens (7.2%) and 42 resection specimens (13.4%). The most common variant morphologic pattern was squamous differentiation (16 cases, 4.5%) followed by an inverted growth pattern (8 cases, 2.2%). The presence of variant morphology in resection specimens had a significant association with higher tumor grade, higher pT stage, and nonpapillary configuration. Of 69 patients with biopsies, 31 had a subsequent resection. In comparison, 181 cons...Continue Reading

Citations

Feb 19, 2019·American Journal of Clinical Pathology·Aileen Grace P ArriolaPriti Lal
Apr 5, 2019·World Journal of Urology·Mudhar N HasanMarianne Brehmer
May 18, 2019·American Society of Clinical Oncology Educational Book·Jeanny B Aragon-ChingEvan Y Yu
Jan 18, 2020·Virchows Archiv : an International Journal of Pathology·Inês RolimAntonio Lopez-Beltran
Mar 28, 2019·World Journal of Urology·Grzegorz FojeckiMarianne Brehmer
Dec 17, 2020·Cancers·Claudia Manini, José I López

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