Variant Salmonella genomic island 1 antibiotic resistance gene cluster containing a novel 3'-N-aminoglycoside acetyltransferase gene cassette, aac(3)-Id, in Salmonella enterica serovar newport

Antimicrobial Agents and Chemotherapy
Benoît DoubletAxel Cloeckaert

Abstract

Salmonella genomic island 1 (SGI1) harbors an antibiotic resistance gene cluster and was previously identified in the multidrug-resistant Salmonella enterica serovars Typhimurium DT104, Agona, Paratyphi B, and Albany. This antibiotic resistance gene cluster is a complex class 1 integron and most often confers resistance to ampicillin (Ap), chloramphenicol (Cm)/florfenicol (Ff), streptomycin (Sm)/spectinomycin (Sp), sulfonamides (Su), and tetracycline (Tc) (ApCmFfSmSpSuTc profile). Recently, variant SGI1 antibiotic resistance gene clusters conferring different antibiotic resistance profiles have been identified in several S. enterica serovars and were classified as SGI1-A to -G. We identified a new variant SGI1 antibiotic resistance gene cluster in two multidrug-resistant S. enterica serovar Newport strains isolated from humans in France. In these strains, the Sm/Sp resistance gene cassette aadA2 inserted at the first attI1 site was replaced by two other aminoglycoside resistance gene cassettes. The first one contains a new resistance gene encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase that confers resistance to gentamicin (Gm) and sisomicin (Sc). This gene has been named aac(3)-Id. The second one harbors the Sm/Sp re...Continue Reading

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Citations

Jul 18, 2006·Nature Reviews. Microbiology·Didier Mazel
Mar 10, 2011·Foodborne Pathogens and Disease·Jonathan G FryePaula J Fedorka-Cray
Apr 13, 2013·The Journal of Antimicrobial Chemotherapy·Eliane Siebor, Catherine Neuwirth
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Sep 13, 2006·Antimicrobial Agents and Chemotherapy·Axel CloeckaertFrançois-Xavier Weill
Nov 19, 2008·Antimicrobial Agents and Chemotherapy·Benoît DoubletAxel Cloeckaert
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