Variants in TERT influencing telomere length are associated with paranoid schizophrenia risk

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Shu-Quan RaoQi Xu

Abstract

Schizophrenia is one of the most severe psychiatric disorders, with a high heritability of up to 80%. Several studies have reported telomere dysfunction in schizophrenia, and common variants in the telomerase reverse transcriptase (TERT) gene. TERT is a key component of the telomerase complex that maintains telomere length by addition of telomere repeats to telomere ends, and has repeatedly shown association with mean lymphocyte telomere length (LTL). Thus, we hypothesized that TERT may be a novel susceptibility gene for schizophrenia. Using a Taqman protocol, we genotyped eight tag SNPs from the TERT locus in 1,072 patients with paranoid schizophrenia and 1,284 control subjects from a Chinese Han population. We also measured mean LTL in 98 cases and 109 controls using a quantitative PCR-based technique. Chi-square tests showed that two SNPs, rs2075786 (P = 0.0009, OR = 0.76, 95%CI = 0.65-0.90) and rs4975605 (P = 0.0026, OR = 0.73, 95%CI = 0.60-0.90), were associated with a protective effect, while rs10069690 was associated with risk of paranoid schizophrenia (P = 0.0044, OR = 1.23, 95%CI = 1.07-1.42). Additionally, the rs2736118-rs2075786 haplotype showed significant association with paranoid schizophrenia (P = 0.0013). Moreov...Continue Reading

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Citations

Sep 3, 2016·Neuroscience Letters·Zhimin RenShuquan Rao
Nov 12, 2016·Journal of Psychiatric Research·Owen M WolkowitzHelena Kraemer
Dec 22, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Nancy Monroy-JaramilloConsuelo Walss-Bass
Feb 13, 2018·Biomedical Reports·E VakonakiA M Tsatsakis
Sep 1, 2017·Biomarkers in Medicine·Ismail ThanseemAyyappan Anitha
May 1, 2021·Journal of Biochemical and Molecular Toxicology·Amrita BhatRakesh Kumar
Jul 17, 2021·Psychoneuroendocrinology·Fernanda TalaricoSintia I Belangero

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