Variants in the nestin gene and coronary heart disease

Circulation Journal : Official Journal of the Japanese Circulation Society
Weihua MengPascal P McKeown

Abstract

The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.

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Citations

Nov 10, 2009·Experimental Cell Research·Hiroki OikawaKenji Sobue
Apr 5, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Michael SkwirbaVeronika Grau

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