Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease

Pediatrics
Yu-Cheng LinYen-Hsuan Ni

Abstract

Oxidative stress is increased in nonalcoholic fatty liver disease (NAFLD). Variants in the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an antioxidant. We hypothesize that variant UGT1A1 genotypes reduce the risk for NAFLD development. Two hundred thirty-four obese children 6 to 13 years of age were recruited. NAFLD was determined through liver ultrasonography. The UGT1A1 genotypes UGT1A1*6 and UGT1A1*28 were detected. We assessed the effects of UGT1A1 genotypes on pediatric NAFLD. In total, 12% of the obese children had NAFLD. The subjects with NAFLD had lower serum total bilirubin levels (0.25 +/- 0.30 mg/dL) than did those without NAFLD (0.36 +/- 0.38 mg/dL; P = .021). With conditioning on the effects of age- and gender-adjusted BMI, waist/hip ratio, and adiponectin levels, variant UGT1A1*6 genotypes were a protecting factor for NAFLD, with an estimated adjusted odds ratio of 0.31 (95% confidence interval: 0.11-0.91; P = .033), but variant UGT1A1*28 genotypes were not significantly associated with the occurrence of NAFLD. Variant UGT1A1*6 genotypes are associated with a lower risk of NAFLD in obese Taiwanese children. The UGT1A1 genotype is a new risk factor for pediatric NAFLD.

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R StockerB N Ames
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·E BeutlerA Demina
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Apr 20, 2000·The Journal of Clinical Investigation·I A LeclercqG R Robertson
Mar 2, 2002·Journal of Clinical Gastroenterology·Arthur J McCullough
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·David E BarananoSolomon H Snyder
Feb 15, 2003·The American Journal of Cardiology·Luc DjousséR Curtis Ellison
Jul 28, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D F Y ChanE A S Nelson
Aug 21, 2004·Pediatric Research·May-Jen HuangChing-Shan Huang
Mar 15, 2005·Journal of Hepatology·Lucia MalaguarneraMariano Malaguarnera
Mar 24, 2005·The American Journal of Gastroenterology·Zeki YesilovaKemal Dagalp
Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Valerio NobiliFiorella Piemonte
Apr 20, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·I JanssenUNKNOWN Health Behaviour in School-Aged Children Obesity Working Group
Jun 14, 2005·Trends in Molecular Medicine·Igino RigatoClaudio Tiribelli
Sep 16, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Gabriel PerlemuterCatherine Buffet
Jun 5, 2007·Clinics in Liver Disease·Phunchai Charatcharoenwitthaya, Keith D Lindor

❮ Previous
Next ❯

Citations

Jan 14, 2011·Journal of Gastroenterology and Hepatology·Shivakumar ChitturiGeoff Farrell
Mar 6, 2012·BMC Genomics·Zhen YangXufang Liang
Jan 20, 2011·Journal of Lipid Research·Amanda J HooperJohn R Burnett
May 21, 2014·Pathology, Research and Practice·Mustafa CengizSeren Ozenirler
Jan 18, 2012·Nature Reviews. Gastroenterology & Hepatology·Anna AlisiValerio Nobili
Mar 8, 2012·Journal of Pediatric Gastroenterology and Nutrition·Pietro VajroValerio Nobili
Mar 23, 2013·Journal of Pediatric Gastroenterology and Nutrition·Kanika PuriNaim Alkhouri
May 18, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Herbert Tilg, Alexander Moschen
Apr 12, 2011·Expert Review of Gastroenterology & Hepatology·Ann K DalyChristopher P Day
May 1, 2012·Alimentary Pharmacology & Therapeutics·M HjelkremS A Harrison
Apr 3, 2013·Genomics·Adviti NaikDamjana Rozman
Apr 4, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P-F ChangY-H Ni
Jan 17, 2013·Clinical and Molecular Hepatology·Byoung Kuk Jang
Jun 18, 2016·International Journal of Molecular Sciences·Jonathan L TempleJude A Oben
Jul 28, 2016·Antioxidants & Redox Signaling·Schohraya SpahisEmile Levy
Mar 2, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lauren WeaverTerry D Hinds
Jan 10, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Yu-Cheng LinYen-Hsuan Ni
May 30, 2019·Hormones : International Journal of Endocrinology and Metabolism·Flora TzifiChristina Kanaka-Gantenbein
May 28, 2020·Scientific Reports·Steffen LandererChristian P Strassburg
Apr 11, 2018·American Journal of Physiology. Renal Physiology·Samuel O AdeosunDavid E Stec
Dec 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Justin F CreedenTerry D Hinds
Dec 29, 2020·Frontiers in Pediatrics·Yu-Cheng LinYen-Hsuan Ni
Feb 8, 2018·Trends in Endocrinology and Metabolism : TEM·Abdul-Rizaq HamoudTerry D Hinds
Apr 29, 2021·Antioxidants & Redox Signaling·Libor Vítek
Dec 2, 2009·Pediatrics·Ezequiel Neimark, Neal S LeLeiko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.