Variants of contextual fear conditioning induce differential patterns of Egr-1 activity within the young adult prefrontal cortex.

Behavioural Brain Research
T ChakrabortyJeffrey B Rosen

Abstract

Contextual fear conditioning is a form of associative learning where animals must experience a context before they can associate it with an aversive stimulus. Single-trial contextual fear conditioning (sCFC) and the context preexposure facilitation effect (CPFE) are two variants of CFC where learning about the context is temporally contiguous (sCFC) with or separated (CPFE) from receiving a footshock in that context. Neural activity within CA1 of the dorsal hippocampus (CA1), amygdala (LA), and prefrontal cortex (PFC) may play a critical role when animals learn to associate a context with a footshock (i.e., training). Previous studies from our lab have found that early-growth-response gene 1 (Egr-1), an immediate early gene, exhibits unique patterns of activity within regions of the PFC following training in sCFC and the CPFE of juvenile rats. In the present study, we extended our studies by examining Egr-1 expression in young adult rats to determine (1) if our previous work reflected changes unique to development or extend into adulthood and (2) to contrast expression profiles between sCFC and the CPFE. Rats that learned context fear with sCFC showed increased Egr-1 in the anterior cingulate, orbitofrontal and infralimbic cort...Continue Reading

References

Mar 1, 1969·Journal of Comparative and Physiological Psychology·R J Blanchard, D C Blanchard
May 10, 2000·Behavioural Brain Research·M E Stanton
Mar 23, 2001·Hippocampus·S G AnagnostarasM S Fanselow
Aug 1, 2002·Behavioral Neuroscience·Jerry W RudyRandall C O'Reilly
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patricia Matus-AmatJerry W Rudy
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·J W RudyP Matus-Amat
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole C HuffJerry W Rudy
Feb 28, 2006·Biological Psychology·Jeffrey B Rosen, Melanie P Donley
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin A Corcoran, Gregory J Quirk
Dec 25, 2007·Biological Psychiatry·Stephanie BissièreJohn F Cryan
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edwin SantiniJames T Porter
Jan 8, 2009·Physiological Reviews·Cristina M Alberini
Oct 15, 2009·Behavioral Neuroscience·M A BurmanM E Stanton
Nov 12, 2009·Nature Reviews. Neuroscience·Geoffrey SchoenbaumYuji K Takahashi
Mar 23, 2010·Current Opinion in Neurobiology·Francisco Sotres-Bayon, Gregory J Quirk
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Sheena A Josselyn
Oct 14, 2010·Behavioral Neuroscience·Teri M FurlongGavan P McNally
Oct 19, 2010·Neuroscience and Biobehavioral Reviews·Laurence Fiddick
Oct 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Demetrio Sierra-MercadoGregory J Quirk
Dec 2, 2010·Frontiers in Behavioral Neuroscience·Jonathan L C Lee
Dec 7, 2010·Neurobiology of Learning and Memory·Felipe L SchiffinoMark E Stanton
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nashat AbumariaGuosong Liu
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Siobhan S PattwellFrancis S Lee
Oct 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ewelina KnapskaLeszek Kaczmarek
May 3, 2013·Nature Reviews. Neuroscience·Stephen MarenIsrael Liberzon
May 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Moriel ZelikowskyMichael S Fanselow

❮ Previous
Next ❯

Citations

Apr 25, 2020·FEBS Letters·Nimrod Madrer, Hermona Soreq
Sep 14, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wookbong KwonZae Young Ryoo
Dec 19, 2018·Brain Structure & Function·Sabrina van HeukelumJ C Glennon
Aug 18, 2017·Learning & Memory·Melanie P Donley, Jeffrey B Rosen
Dec 21, 2020·Neurobiology of Aging·Stephanie M MuscatRuth M Barrientos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.