Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown. We carried out a genomewide association study involving children with asthma. The sample included 793 North American children of European ancestry with persistent asthma who required daily inhaled glucocorticoid therapy and 1988 matched controls (the discovery set). We also tested for genomewide association in an independent cohort of 917 persons of European ancestry who had asthma and 1546 matched controls (the replication set). Finally, we tested for an association between 20 single-nucleotide polymorphisms (SNPs) at chromosome 1q31 and asthma in 1667 North American children of African ancestry who had asthma and 2045 ancestrally matched controls. In our meta-analysis of all samples from persons of European ancestry, we observed an association, with genomewide significance, between asthma and SNPs at the previously reported locus on 17q21 and an additional eight SNPs at a novel locus on 1q31. The SNP most strongly associated with asthma was rs2786098 (P=8.55x10(-9)). We observed replication of the association of asthma with SNP rs2786098 in the independent series of person...Continue Reading
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma
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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans
Getting from genes to function in lung disease: a National Heart, Lung, and Blood Institute workshop report
Elevated eosinophil protein X in urine from healthy neonates precedes development of atopy in the first 6 years of life
Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study
Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1
Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons
Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants
A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.
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