Variants of DENND1B associated with asthma in children

The New England Journal of Medicine
Patrick M A SleimanHakon Hakonarson

Abstract

Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown. We carried out a genomewide association study involving children with asthma. The sample included 793 North American children of European ancestry with persistent asthma who required daily inhaled glucocorticoid therapy and 1988 matched controls (the discovery set). We also tested for genomewide association in an independent cohort of 917 persons of European ancestry who had asthma and 1546 matched controls (the replication set). Finally, we tested for an association between 20 single-nucleotide polymorphisms (SNPs) at chromosome 1q31 and asthma in 1667 North American children of African ancestry who had asthma and 2045 ancestrally matched controls. In our meta-analysis of all samples from persons of European ancestry, we observed an association, with genomewide significance, between asthma and SNPs at the previously reported locus on 17q21 and an additional eight SNPs at a novel locus on 1q31. The SNP most strongly associated with asthma was rs2786098 (P=8.55x10(-9)). We observed replication of the association of asthma with SNP rs2786098 in the independent series of person...Continue Reading

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Related Concepts

Genome-Wide Association Study
Chromosomes, Human, Pair 1
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptor
African Continental Ancestry Group
Natural Killer Cell Count
DENND1B gene
Odds Ratio

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