Abstract
Genome-wide association study (GWAS) has determined the metabotropic glutamate receptor 7 (GRM7) gene as potential locus for schizophrenia risk variants; However, the relationship between the GRM7 variants and the risk of schizophrenia is still uncertain, and there are significant individual variations in response to the antipsychotic drugs. In order to identify susceptible gene and drug-response-related markers, 2413 subjects in our research were chosen for determining drug-response-related markers in schizophrenia. The rs1516569 variant (OR = 0.95, P < 3.47 × 10-4) was a significant risk factor, and a single-nucleotide polymorphism of GRM7 gene- rs9883258 (OR = 0.84, P = 2.18 × 10-3) has been determined as potential biomarkers for therapeutic responses of seven commonly used antipsychotic drugs (aripiprazole, haloperidol, olanzapine, perphenazine, quetiapine, risperidone and ziprasidone) in Chinese Han population; Significant associations with treatment response for several single-nucleotide polymorphisms in every antipsychotic drugs, such as rs779746 (OR = 1.39, P = 0.03), rs480409 (OR = 0.73, P = 0.04), rs78137319 (OR = 3.09, P = 0.04), rs1154370 (OR = 1.51, P = 0.006) have been identified in our study. Hence our research e...Continue Reading
References
Aug 19, 1995·Lancet·N C Andreasen
Jan 1, 1997·Life Sciences·A CarlssonM L Carlsson
Sep 20, 2000·Psychiatric Genetics·N J BrayM J Owen
Feb 13, 2001·Schizophrenia Research·A A BolonnaA J Makoff
Mar 20, 2002·Progress in Neurobiology·Audrey ClaingRobert J Lefkowitz
Nov 12, 2003·The Pharmacogenomics Journal·Y YamanouchiN Ozaki
Jun 6, 2007·Molecular Psychiatry·M J Arranz, J de Leon
Mar 19, 2008·Molecular Psychiatry·P F SullivanS L Close
Jan 22, 2009·European Journal of Human Genetics : EJHG·Anna C NeedDavid B Goldstein
Apr 9, 2009·Psychiatry Research·Hiroki ShibataYasuyuki Fukumaki
Jul 17, 2010·Bioinformatics·Randall J PruimCristen J Willer
Nov 12, 2010·Nature·Jim van OsBart P F Rutten
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Sep 1, 2014·Nature Neuroscience·Adaikalavan RamasamyMichael E Weale
Sep 17, 2014·ACS Chemical Neuroscience·Nidhi Jalan-SakrikarColleen M Niswender
Apr 30, 2015·Stem Cell Reports·Wenlong XiaJianwei Jiao
Dec 15, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Wenjin LiYongyong Shi
Feb 10, 2016·The Pharmacogenomics Journal·E SacchettiM Gennarelli
Feb 26, 2016·Translational Psychiatry·J M StevensonJ R Bishop
Dec 7, 2016·Molecular Psychiatry·H YuW Yue
Apr 23, 2017·Schizophrenia Research·Jiang LiHerbert Y Meltzer
Sep 1, 2017·The Journal of Comparative Neurology·Xing ChenGang Chen
Oct 11, 2017·Biological Psychiatry·Rikke HilkerBirte Glenthøj
Feb 28, 2018·Nature Genetics·Antonio F PardiñasJames T R Walters
Mar 6, 2018·The Lancet. Psychiatry·Hao YuUNKNOWN Chinese Antipsychotics Pharmacogenomics Consortium
Jul 28, 2018·Nature Neuroscience·Andrew E JaffeDaniel R Weinberger
Nov 9, 2018·Frontiers in Molecular Neuroscience·Nicole M FisherColleen M Niswender
Mar 19, 2019·Pharmacogenomics·Josiah D Allen, Jeffrey R Bishop
Nov 20, 2019·Nature Genetics·Max LamHailiang Huang