Variants of the ADRB2 Gene in COPD: Systematic Review and Meta-Analyses of Disease Risk and Treatment Response

COPD
Anne Orholm NielsenM Dahl

Abstract

The β2-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle tone in chronic obstructive pulmonary disease (COPD). Variants that impair ADRB2 function could increase disease risk or reduce the response to endogenous and inhaled adrenergic agonists in COPD. We performed a systematic review and three meta-analyses to assess whether three functional variants (Thr164Ile, Arg16Gly, and Gln27Glu) in the ADRB2 gene are associated with elevated risk of disease or reduced therapeutic response to inhaled β2-agonists in COPD. We searched the medical literature from 1966 to 2017 and found 16 relevant studies comprising 85381 study subjects. The meta-analyses found no significant association between ADRB2 genotype and COPD risk. The summary odds ratios (ORs) for COPD in Thr164Ile homozygotes and heterozygotes were 2.57 (95% confidence interval (CI): 0.54-12.4) and 1.17 (95% CI: 0.96-1.44), respectively. Corresponding summary ORs for COPD in Arg16Gly homozygotes and heterozygotes were 0.97 (95% CI: 0.76-1.22) and 1.01 (95% CI: 0.81-1.26), while summary ORs for COPD in Gln27Glu homozygotes and heterozygotes were 1.00 (95% CI: 0.80-1.25) and 0.94 (95% CI: 0.69-1.24), respectively. When stratified by ethnicity, the summa...Continue Reading

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Citations

Mar 31, 2019·Expert Review of Respiratory Medicine·Craig P Hersh
Jun 2, 2018·Current Medicinal Chemistry·Patrizia RussoMassimo Fini
Feb 9, 2020·The Clinical Respiratory Journal·Almira AkparovaRakhmetkazhi Bersimbaev
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Dec 19, 2019·Pharmacological Reviews·M G MateraM Cazzola
Dec 11, 2020·Life Sciences·Ailin YangHaoyan Wang
Nov 12, 2020·Ciência & saúde coletiva·Marina Malheiro Cruz, Marcos Pereira
Jul 6, 2021·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Qing GanYong Dai
Jul 13, 2019·Respiratory Medicine·Lynn D CondreaySoumitra Ghosh

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