Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults.

Journal of Strength and Conditioning Research
Katherine N Van DeveireLinda S Pescatello

Abstract

Ankyrin repeat domain 6 (ANKRD6) is a ubiquitous protein that associates with early development in mammals and is highly expressed in the brain, spinal cord, and heart of humans. We examined the role of 8 ANKRD6 single-nucleotide polymorphisms (SNPs) on muscle performance and habitual physical activity (PA). Single-nucleotide polymorphisms were 545 T>A (rs9362667), 485 M>L (rs61736690), 233 T>M (rs2273238), 128 I>L (rs3748085), 631 P>L (rs61739327), 122 Q>E (rs16881983), 197805 G>A (rs9344950), and 710 L>X (NOVEL). This study consisted of 922 healthy, untrained, European-derived American men (n = 376, 23.6 ± 0.3 years, 25.0 ± 0.2 kg·m(-2)) and women (n = 546, 23.2 ± 0.2 years, 24.0 ± 0.2 kg·m(-2)). Muscle strength (maximum voluntary contraction [MVC] and 1 repetition maximum [1RM]) and size (cross-sectional area [CSA]) were assessed before and after 12 weeks of unilateral resistance training (RT). A subsample (n = 536, 23.4 ± 0.2 years, 24.6 ± 0.2 kg·m(-2)) completed the Paffenbarger Physical Activity Questionnaire. Associations among ANKRD6 genotypes and muscle phenotypes were tested with repeated measure analysis of covariance (ANCOVA) and PA phenotypes with multivariate ANCOVA, with age and body mass index as covariates. ANK...Continue Reading

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Citations

Jan 1, 2014·Journal of Strength and Conditioning Research·Monica J HubalMaren S Fragala
Apr 2, 2015·Journal of Affective Disorders·Shanker SwaminathanJohn I Nurnberger
May 12, 2017·Cold Spring Harbor Perspectives in Medicine·Marcas M BammanGregory R Adams
Jan 24, 2021·The International Journal of Behavioral Nutrition and Physical Activity·Lene AasdahlEivind Schjelderup Skarpsno
Apr 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher G VannMichael D Roberts

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