Abstract
Ankyrin repeat domain 6 (ANKRD6) is a ubiquitous protein that associates with early development in mammals and is highly expressed in the brain, spinal cord, and heart of humans. We examined the role of 8 ANKRD6 single-nucleotide polymorphisms (SNPs) on muscle performance and habitual physical activity (PA). Single-nucleotide polymorphisms were 545 T>A (rs9362667), 485 M>L (rs61736690), 233 T>M (rs2273238), 128 I>L (rs3748085), 631 P>L (rs61739327), 122 Q>E (rs16881983), 197805 G>A (rs9344950), and 710 L>X (NOVEL). This study consisted of 922 healthy, untrained, European-derived American men (n = 376, 23.6 ± 0.3 years, 25.0 ± 0.2 kg·m(-2)) and women (n = 546, 23.2 ± 0.2 years, 24.0 ± 0.2 kg·m(-2)). Muscle strength (maximum voluntary contraction [MVC] and 1 repetition maximum [1RM]) and size (cross-sectional area [CSA]) were assessed before and after 12 weeks of unilateral resistance training (RT). A subsample (n = 536, 23.4 ± 0.2 years, 24.6 ± 0.2 kg·m(-2)) completed the Paffenbarger Physical Activity Questionnaire. Associations among ANKRD6 genotypes and muscle phenotypes were tested with repeated measure analysis of covariance (ANCOVA) and PA phenotypes with multivariate ANCOVA, with age and body mass index as covariates. ANK...Continue Reading
References
Sep 1, 1978·American Journal of Epidemiology·R S PaffenbargerR T Hyde
Sep 1, 1987·Annals of Human Biology·L PérusseC Bouchard
Dec 1, 1993·Journal of Clinical Epidemiology·B E AinsworthR S Paffenbarger
Jan 1, 1993·Medicine and Science in Sports and Exercise·R S PaffenbargerR T Hyde
May 20, 1998·Medicine and Science in Sports and Exercise·M A ThomisR F Vlietinck
Jul 2, 1998·Acta Physiologica Scandinavica·M A ThomisR F Vlietinck
Jun 28, 2001·Physiological Reviews·V Bennett, A J Baines
Aug 17, 2002·Genes & Development·Thomas Schwarz-RomondWalter Birchmeier
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F TissirC Lambert De Rouvroit
Apr 2, 2003·Psychopharmacology·J S Rhodes, T Garland
Sep 5, 2003·Psychopharmacology·James P Zacny, Sandra Gutierrez
Jul 6, 2004·Medicine and Science in Sports and Exercise·Paul D ThompsonEric P Hoffman
Dec 8, 2005·The American Journal of Clinical Nutrition·Annemiek M C P JoosenKlaas R Westerterp
Jun 16, 2006·Medicine and Science in Sports and Exercise·Linda S PescatelloEric P Hoffman
Aug 5, 2006·Medicine and Science in Sports and Exercise·Sofia CarlssonAnders Ahlbom
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Heinz MoellerWalter Birchmeier
Nov 4, 2006·Cell·Hans Clevers
Dec 22, 2006·PloS One·Janine H StubbeEco J C de Geus
Feb 3, 2007·Journal of Applied Physiology·Gunther De MarsMartine A I Thomis
Aug 19, 2007·European Journal of Human Genetics : EJHG·Marleen H M De MoorEco J C De Geus
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Apr 7, 2009·Medicine and Science in Sports and Exercise·Matthew A KostekLinda S Pescatello
Jun 13, 2009·Behavioural Brain Research·Amy M KnabJ Timothy Lightfoot
Jul 25, 2009·Journal of Applied Physiology·Sean WalshLinda S Pescatello
Sep 4, 2009·Medicine and Science in Sports and Exercise·Marleen H M De MoorHong-Wen Deng
Citations
Jan 1, 2014·Journal of Strength and Conditioning Research·Monica J HubalMaren S Fragala
Jun 9, 2015·Meat Science·J HorodyskaR M Hamill
Jan 16, 2016·Age·Juha P AhtiainenKeijo Häkkinen
Jan 24, 2014·BioMed Research International·Linda S PescatelloEric P Hoffman
Apr 2, 2015·Journal of Affective Disorders·Shanker SwaminathanJohn I Nurnberger
May 12, 2017·Cold Spring Harbor Perspectives in Medicine·Marcas M BammanGregory R Adams
Feb 6, 2019·Endocrinology·Xueying Zhang, John R Speakman
Sep 21, 2012·BMC Musculoskeletal Disorders·George A KelleyWendy M Kohrt
Jan 24, 2021·The International Journal of Behavioral Nutrition and Physical Activity·Lene AasdahlEivind Schjelderup Skarpsno
Apr 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher G VannMichael D Roberts