Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
C HerderT Illig

Abstract

Genome-wide association (GWA) studies identified novel gene variants that are associated with type 2 diabetes. However, results were not always consistent across different populations. Thus, the aims of this study were (i) to replicate findings from previous GWA studies in mainly Northern European populations using data from the German KORA 500 K diabetes project and (ii) to assess the impact of BMI on associations between single nucleotide polymorphisms (SNPs) and type 2 diabetes. The KORA 500 K diabetes project includes 433 cases with validated type 2 diabetes and 1 438 nondiabetic controls from two population-based KORA surveys. Genotyping was performed using the Affymetrix GeneChip Human Mapping 500 K Array Set. We investigated associations between SNPs and type 2 diabetes in 10 genes that have been reported to increase the risk of type 2 diabetes or were in complete or near-complete linkage disequilibrium with these variants. SNPs in the CDKAL1 gene showed the strongest association with type 2 diabetes [range of age and sex-adjusted odds ratios (OR): 1.30-1.39, p-values 0.0008-0.0004]. In addition, we found evidence for association of SNPs in the genes PPARG, IGF2BP2, HHEX, TCF7L2, and FTO with type 2 diabetes in the same ...Continue Reading

Citations

Dec 9, 2008·Nature Genetics·Inga ProkopenkoGonçalo R Abecasis
Oct 29, 2011·DNA and Cell Biology·Yuan ZhaoXiao-Feng Wang
Apr 25, 2009·PPAR Research·Weimin He
May 28, 2013·Journal of Diabetes Research·Gabriela da Silva XavierGuy A Rutter
Jul 10, 2012·Journal of Diabetes and Its Complications·Tianwei GuHarvest F Gu
Jun 29, 2010·Metabolism: Clinical and Experimental·Manickam ChidambaramViswanathan Mohan
Mar 9, 2011·Diabetes/metabolism Research and Reviews·Guenther SilbernagelBernhard O Boehm
Jan 5, 2011·European Journal of Clinical Investigation·Christian Herder, Michael Roden
Sep 15, 2009·Endocrine Reviews·Harald StaigerHans-Ulrich Häring
Jun 1, 2011·Molecular Biology Reports·Xiao Yun BaoMao Sheng Yang
Jun 27, 2019·Journal of Cellular Biochemistry·Hamidreza GalaviHojat Shahraki
Feb 12, 2021·Cancer Cell International·Jinyan WangPing Qiang
Mar 27, 2020·Saudi Journal of Biological Sciences·Richard L JayarajRami Beiram
Jan 16, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Chuanyin LiYiping Li

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