Variation at 10 protein coding loci in the Mbenzele Pygmies from the Central African Republic and a comparison with microsatellite data

American Journal of Human Biology : the Official Journal of the Human Biology Council
Valentina CoiaGiovanni Destro-Bisol

Abstract

Ten protein coding loci (6-PGD, A1-AT, ACP1, CaII, ESD, GC, GPX1, Hb beta, PGM1, and TF) were analyzed in the Mbenzele Pygmies from the Central African Republic. The frequency data were used to calculate the genetic distances between Mbenzele Pygmies and other African groups. In the principal coordinate plot of FST genetic distances, the Mbenzele cluster together with other Pygmies of the western cluster, the Biaka from C.A.R., Gielli from Cameroon, and Babinga from Congo. By contrast, they are considerably distanced from other Pygmy groups of the eastern cluster (Twa from Rwanda, Mbuti from Zaire). Genetic distances obtained using protein loci were compared with those based on microsatellite loci. The two distance matrices are insignificantly correlated (r = 0.268; one tail probability = 0.332), and the main difference is in the higher genetic affinity between the Mbenzele and Biaka Pygmies observed at the protein level. Although reasons underlying the discrepancy between inter-populational variation at protein and DNA loci are not established with certainty, the comparison suggests that the genetic distance between the Mbenzele and Biaka Pygmies at microsatellite loci could have been shaped by genetic drift.

References

Dec 1, 1972·Journal of Medical Genetics·E BottiniF Gloria
Jul 1, 1996·American Journal of Physical Anthropology·B T Shea, R C Bailey
Nov 1, 1996·Genetics·A MochizukiY Iwasa
Jan 1, 1997·Human Genetics·A Pérez-LezaunJ Bertranpetit
Jan 1, 1997·International Journal of Legal Medicine·M KayserL Roewer
Oct 22, 1998·European Journal of Human Genetics : EJHG·F CalafellK K Kidd
Sep 29, 1999·American Journal of Physical Anthropology·G SpediniG Paoli
Jun 22, 2000·American Journal of Physical Anthropology·G Destro-BisolG Spedini
Sep 12, 2000·Human Genetics·G Destro-BisolV L Pascali
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Giovanni Destro-BisolGabriella Spedini

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Citations

Dec 23, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Valentina CoiaChris Tyler-Smith
Jun 24, 2014·Studies in History and Philosophy of Biological and Biomedical Sciences·Soraya de Chadarevian
Dec 14, 2005·American Journal of Physical Anthropology·Alan G Morris, Isabelle Ribot

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