PMID: 173280Oct 1, 1975

Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster

Biochemical Genetics
E W ThörigW Scharloo

Abstract

A new variant of alcohol dehydrogenase (ADH 7lk) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperature between 15 and 25 C. But while ADH F enzyme is inactivated rapidly at 40 C, ADH 7lk is still active. Also, ADH S is not inactivated at this temperature, but has a far lower activity per fly than ADH 7lk. Genetic analysis showed that the new variant is an allele of the Adh locus.

References

Aug 29, 1970·Nature·J B Gibson
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S C BernsteinJ L Hubby
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S SinghR C Lewontin
Jun 1, 1971·Theoretical Population Biology·M Kimura
Sep 1, 1957·Biochimica Et Biophysica Acta·J R FLORINI, C S VESTLING

Citations

Apr 1, 1978·Biochemical Genetics·N Lewis, J Gibson
Dec 1, 1978·Biochemical Genetics·B Sampsell, R Milkman
Oct 1, 1993·Biochemical Genetics·A Freriksen, P W Heinstra
Dec 1, 1988·Journal of Molecular Evolution·P W HeinstraG E Thörig
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J M NaiduH W Mohrenweiser
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·K T EissesG E Thörig
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H W Mohrenweiser, J V Neel

Related Concepts

Alcohol Oxidoreductases
Ethanol
Alleles
Metazoa
Genome Mapping
Drosophila melanogaster
SDS-PAGE
NADH
Recombination, Genetic
Variation (Genetics)

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