Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate

The British Journal of Dermatology
Cindy M de JonghSanja Kezic

Abstract

Skin irritability after a brief exposure to the model skin irritant, sodium lauryl sulphate (SLS), is known to vary considerably between individuals. A difference in the skin barrier to SLS may contribute to this variation. To date, no human in vivo data have been available on SLS penetration into the skin. We studied whether the SLS penetration rate into the stratum corneum (SC) is related to impairment of the water barrier function and inflammation of the skin. The penetration of SLS into the SC was assessed using a noninvasive tape-stripping procedure in 20 volunteers after a 4-h exposure to 1% SLS. Additionally, the effect of a 24-h exposure to 1% SLS on the skin water barrier function was assessed by measuring the transepidermal water loss (TEWL). The accompanying inflammation was quantified by measuring erythema. The mean +/- SD diffusivity of SLS (D) and the SLS permeability coefficient (Kp) were 1.4 +/- 0.6 x 10(-8) cm2 h(-1) and 1.5 +/- 0.7 x 10(-3) cm h(-1), respectively. A multiple regression analysis showed that the baseline TEWL, SC thickness and SLS penetration parameters K (SC/water partition coefficient) and D clearly influenced the increase in TEWL after the 24-h irritation test (explained variance: r2 = 0.80)....Continue Reading

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Citations

Feb 25, 2009·International Archives of Occupational and Environmental Health·Sanja Kezic, J B Nielsen
Jun 22, 2006·Contact Dermatitis·Cindy M De JonghSanja Kezic
Aug 29, 2012·Dermatology Research and Practice·Russel M WaltersSidney Hornby
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Oct 3, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Cindy M de JonghSanja Kezic
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May 3, 2021·Clinical Physiology and Functional Imaging·Hemalatha JayabalDan L Bader
Jul 16, 2021·Clinical Reviews in Allergy & Immunology·Yan Li, Linfeng Li

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