Variation in body composition determines long-term blood pressure changes in pre-hypertension: the MONICA/KORA (Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Research in the Region of Augsburg) cohort study

Journal of the American College of Cardiology
Marcello Ricardo Paulista MarkusMONICA/KORA Investigators

Abstract

We studied the relationship between changes in body composition and changes in blood pressure levels. The mechanisms underlying the frequently observed progression from pre-hypertension to hypertension are poorly understood. We examined 1,145 subjects from a population-based survey at baseline in 1994/1995 and at follow-up in 2004/2005. First, we studied individuals pre-hypertensive at baseline who, during 10 years of follow-up, either had normalized blood pressure (PreNorm, n = 48), persistently had pre-hypertension (PrePre, n = 134), or showed progression to hypertension (PreHyp, n = 183). In parallel, we studied predictors for changes in blood pressure category in individuals hypertensive at baseline (n = 429). After 10 years, the PreHyp group was characterized by a marked increase in body weight (+5.71% [95% confidence interval (CI): 4.60% to 6.83%]) that was largely the result of an increase in fat mass (+17.8% [95% CI: 14.5% to 21.0%]). In the PrePre group, both the increases in body weight (+1.95% [95% CI: 0.68% to 3.22%]) and fat mass (+8.09% [95% CI: 4.42% to 11.7%]) were significantly less pronounced than in the PreHyp group (p < 0.001 for both). The PreNorm group showed no significant change in body weight (-1.55% [9...Continue Reading

References

May 1, 1991·Annals of Epidemiology·J Stamler
Aug 26, 1998·Journal of the American College of Cardiology·H W HenseH Schunkert
Jan 17, 2002·The New England Journal of Medicine·R S VasanD Levy
Dec 24, 2004·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study Scientific Group
Mar 16, 2006·The New England Journal of Medicine·Heribert Schunkert
Mar 16, 2006·The New England Journal of Medicine·Stevo JuliusUNKNOWN Trial of Preventing Hypertension (TROPHY) Study Investigators
May 14, 2008·Hypertension·David W Harsha, George A Bray
Jul 1, 2009·Hypertension·Franz H Messerli, Harikrishna Makani
Jul 1, 2009·Hypertension·Giuseppe ManciaRoberto Sega

❮ Previous
Next ❯

Citations

Jun 6, 2013·Current Hypertension Reports·Mieczysław LitwinLidia Gackowska
Feb 14, 2013·Clinical and Experimental Hypertension : CHE·Sunjie YanSongjing Zhang
Nov 8, 2014·Journal of Hypertension·Bo Carlberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.