PMID: 9451422Feb 6, 1998Paper

Variation in cell yield and proliferative activity of positive selected human CD34+ bone marrow cells along the circadian time scale

European Journal of Haematology
Jenny Foss AbrahamsenO D Laerum

Abstract

Variations in cell yield and proliferative activity of human bone marrow (BM) progenitor cells were determined with flow cytometry along the 24-h (circadian) time scale. Equal volumes of BM were aspirated every 5 h, altogether 5 times in 5 healthy men. An average 6-fold higher yield of positive selected CD34+ cells occurred in each subject when BM was aspirated during the daytime and late afternoon, while a lower yield occurred during the night. Using all CD34+ cell yield data normalized to percentage of mean, a significant time-effect was found by ANOVA (p = 0.02) and a significant circadian rhythm was detected by the least-squares fit of a 24 h cosine (p = 0.02). The 95% confidence limits of the acrophase (time of highest values) were computed to be at midday between 10:24 and 14:48 h. A highly significant correlation (p = 0.001) was found between proliferation of positive selected CD34+ cells and the more mature myeloid precursor cells from the same BM aspirates, suggesting a common temporal pattern along the circadian time scale. However, no correlation was demonstrated between proliferation and cell yield of CD34+ selected cells, suggesting that mechanisms other than variation in proliferation may cause the circadian rhyth...Continue Reading

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Citations

Nov 17, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Teresa G GrandaFrancis Lévi
May 12, 2004·Journal of Cellular Physiology·Lionel D'HondtPeter J Quesenberry
Apr 19, 2007·Journal of Biological Rhythms·Oleg TsinkalovskyOle Didrik Laerum
Jun 25, 2016·Circulation Research·Cameron S McAlpine, Filip K Swirski
Apr 19, 2002·Chronobiology International·Philippe BourinFrancis Lévi
Apr 19, 2002·Chronobiology International·Rune SmaalandJenny Foss Abrahamsen
May 7, 2009·Current Opinion in Hematology·Simón Méndez-FerrerPaul S Frenette
Nov 21, 2009·Integrative Cancer Therapies·William J M HrusheskyDonald Braun
Oct 7, 2020·Annual Review of Cell and Developmental Biology·Joseph Lewis BedontAmita Sehgal

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