Variation in Childhood Diarrheal Morbidity and Mortality in Africa, 2000-2015

The New England Journal of Medicine
Robert C ReinerSimon I Hay

Abstract

Diarrheal diseases are the third leading cause of disease and death in children younger than 5 years of age in Africa and were responsible for an estimated 30 million cases of severe diarrhea (95% credible interval, 27 million to 33 million) and 330,000 deaths (95% credible interval, 270,000 to 380,000) in 2015. The development of targeted approaches to address this burden has been hampered by a paucity of comprehensive, fine-scale estimates of diarrhea-related disease and death among and within countries. We produced annual estimates of the prevalence and incidence of diarrhea and diarrhea-related mortality with high geographic detail (5 km2) across Africa from 2000 through 2015. Estimates were created with the use of Bayesian geostatistical techniques and were calibrated to the results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016. The results revealed geographic inequality with regard to diarrhea risk in Africa. Of the estimated 330,000 childhood deaths that were attributable to diarrhea in 2015, more than 50% occurred in 55 of the 782 first-level administrative subdivisions (e.g., states). In 2015, mortality rates among first-level administrative subdivisions in Nigeria differed by up to a factor...Continue Reading

References

May 7, 1996·Health Policy and Planning·C G VictoraL C Nobre
Aug 7, 2002·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Luiz Carlos Rangel SoaresSonia Tavares
Mar 14, 2007·BMJ : British Medical Journal·Thomas ClasenSandy Cairncross
Jan 30, 2010·Lancet·Olivier Degomme, Debarati Guha-Sapir
Apr 2, 2010·International Journal of Epidemiology·Sandy CairncrossWolf-Peter Schmidt
Apr 2, 2010·International Journal of Epidemiology·Christa L Fischer Walker, Robert E Black
Apr 2, 2010·International Journal of Epidemiology·Melinda K MunosRobert E Black
Apr 30, 2010·Bulletin of the World Health Organization·Madhu GhimireMahesh Kumar Maskey
Jul 15, 2011·Public Health Nutrition·Mercedes de OnisElaine Borghi
Jun 12, 2012·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Julius N FobilJuergen May
Feb 23, 2013·Journal of Water and Health·Jennyfer WolfAnnette Prüss-Ustün
Oct 23, 2013·Maternal & Child Nutrition·Adelheid W Onyango
Jun 28, 2015·Vaccine·Angel Paternina-CaicedoFernando De la Hoz-Restrepo
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Umesh D ParasharJacqueline E Tate
Jun 3, 2016·The Pediatric Infectious Disease Journal·Laura M LambertiRobert E Black
Oct 11, 2016·The New England Journal of Medicine·Peter W GethingStephen S Lim
Mar 2, 2018·Nature·Nicholas GraetzSimon I Hay
Mar 2, 2018·Nature·Aaron Osgood-ZimmermanSimon I Hay

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Citations

Mar 5, 2019·Current Infectious Disease Reports·James M Fleckenstein, F Matthew Kuhlmann
Jul 25, 2019·Nature Medicine·Natalia V BhattacharjeeSimon I Hay
Jul 30, 2020·Tropical Medicine and Infectious Disease·Mark A Deka
Jul 2, 2020·Pediatric Health, Medicine and Therapeutics·Adane AsefaLemi Abebe
Sep 24, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Tian DuQiu-Hua Mo
Jun 11, 2020·Tropical Medicine and Health·Rodrick R KisengeChristopher P Duggan
Jul 8, 2020·BMC Medicine·Michael A CorkLaura Dwyer-Lindgren
Sep 19, 2019·International Health·Simon I Hay
Nov 17, 2020·Frontiers in Veterinary Science·Lucy J RobertsonGetachew Terefe
Jan 22, 2021·Environmental Science & Technology·Rebecca A SternElsie M Sunderland
Dec 18, 2020·Nature·UNKNOWN Local Burden of Disease Vaccine Coverage Collaborators
Apr 9, 2021·PloS One·Hailing ChangMei Zeng
Apr 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Rockli KimS V Subramanian
May 1, 2021·Nature Communications·Li-Ping WangUNKNOWN Chinese Centers for Disease Control and Prevention (CDC) Etiology of Diarrhea Surveillance Study Team
Jun 9, 2021·BMC Infectious Diseases·Grit SchubertUNKNOWN ANDEMIA consortium
Jul 3, 2021·International Journal of Environmental Research and Public Health·Thi Yen Chi NguyenMohamed Aqiel Dalvie

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